| pubmed-article:6694562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0040160 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0947647 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C0458083 | lld:lifeskim |
| pubmed-article:6694562 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:6694562 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6694562 | pubmed:dateCreated | 1984-3-23 | lld:pubmed |
| pubmed-article:6694562 | pubmed:abstractText | We have recently shown that mouse pituitary concentrations of free TSH-beta and alpha-subunits respond divergently to thyroid hormone manipulations in vivo. This study contrasts the changes in free LH-beta and alpha-subunits after castration and polyestradiol phosphate (E2) administration with those in free TSH-beta and alpha-subunits after thyroidectomy and thyroxine (T4) administration. Target hormone depletion (castration or thyroidectomy) resulted in an increase in plasma concentrations of the respective tropic hormones and their subunits; target hormone administration (E2 or T4) resulted in a decrease in plasma concentrations. In contrast, pituitary subunit concentrations of LH and TSH responded discordantly to target hormone depletion or administration, and the nature of the discordance for alpha-subunit and LH-beta was opposite to that for alpha-subunit and TSH-beta. Hypogonadism caused a decrease in pituitary LH and LH-beta concentrations to 65% (P less than 0.01) and 48% (P less than 0.001) of values in control (eugonadal) mice, respectively, while alpha-subunit was unchanged. Hypothyroidism caused a two-fold (P less than 0.001) and 20-fold (P less than 0.001) increase in pituitary TSH and TSH-beta concentrations, respectively, while alpha-subunit fell to 68% (P less than 0.01) of values in control (euthyroid) mice. Administration of E2 to hypogonadal mice resulted in a two-fold increase in pituitary LH and LH-beta after 11 days, while alpha-subunit fell to 55% (P less than 0.01) of values in control (untreated hypogonadal) mice.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:6694562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6694562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6694562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6694562 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6694562 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:6694562 | pubmed:author | pubmed-author:RidgwayE CEC | lld:pubmed |
| pubmed-article:6694562 | pubmed:author | pubmed-author:ChinW WWW | lld:pubmed |
| pubmed-article:6694562 | pubmed:author | pubmed-author:ReadS ISI | lld:pubmed |
| pubmed-article:6694562 | pubmed:author | pubmed-author:DowningM FMF | lld:pubmed |
| pubmed-article:6694562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6694562 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:6694562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6694562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6694562 | pubmed:pagination | 230-4 | lld:pubmed |
| pubmed-article:6694562 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
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| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:meshHeading | pubmed-meshheading:6694562-... | lld:pubmed |
| pubmed-article:6694562 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6694562 | pubmed:articleTitle | Discordant changes in pituitary concentrations of LH and TSH subunits following hormonal manipulation. | lld:pubmed |
| pubmed-article:6694562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6694562 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6694562 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6694562 | lld:pubmed |
