| pubmed-article:6689959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6689959 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:6689959 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:6689959 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:6689959 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:6689959 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6689959 | pubmed:dateCreated | 1984-2-14 | lld:pubmed |
| pubmed-article:6689959 | pubmed:abstractText | A comparison was made between the properties of the norepinephrine- and caffeine-sensitive Ca2+ store in both intact and skinned smooth muscle of the rabbit mesenteric artery. After a first application of 10(-5) M norepinephrine, reapplication of norepinephrine did not induce a second contraction in Ca2+-free medium. However, following this sequence 25 mM caffeine still induced a large contraction. The rates of Ca2+ leakage and Ca2+ filling of the norepinephrine-sensitive store were much faster than those of the caffeine-sensitive one. The amplitude of the norepinephrine-induced contraction in Ca2+-free medium also depended on the amount of Ca2+ present in the caffeine-sensitive store. In the saponin-treated skinned muscle caffeine induced a Ca2+ release only after loading with Ca2+, whereas norepinephrine was unable to induce Ca2+ release in the skinned preparation even after loading with Ca2+. The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane. In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum. | lld:pubmed |
| pubmed-article:6689959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6689959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6689959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6689959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6689959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6689959 | pubmed:issn | 0303-6847 | lld:pubmed |
| pubmed-article:6689959 | pubmed:author | pubmed-author:SaidaKK | lld:pubmed |
| pubmed-article:6689959 | pubmed:author | pubmed-author:van BreemenCC | lld:pubmed |
| pubmed-article:6689959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6689959 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:6689959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6689959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6689959 | pubmed:pagination | 43-52 | lld:pubmed |
| pubmed-article:6689959 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:6689959 | pubmed:meshHeading | pubmed-meshheading:6689959-... | lld:pubmed |
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| pubmed-article:6689959 | pubmed:meshHeading | pubmed-meshheading:6689959-... | lld:pubmed |
| pubmed-article:6689959 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6689959 | pubmed:articleTitle | Characteristics of the norepinephrine-sensitive Ca2+ store in vascular smooth muscle. | lld:pubmed |
| pubmed-article:6689959 | pubmed:publicationType | Journal Article | lld:pubmed |
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