| pubmed-article:6617239 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0027713 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0205107 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0020544 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0021186 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6617239 | lifeskim:mentions | umls-concept:C0597488 | lld:lifeskim |
| pubmed-article:6617239 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6617239 | pubmed:abstractText | Indapamide, a newly developed antihypertensive agent with modest diuretic properties, reduced mean arterial pressure toward normal in dogs made hypertensive with salt and DOCA, while low-dose furosemide (0.1 mg per day) and hydrochlorothiazide (1 and 50 mg per day) did not result in similar degrees of blood pressure control. Indapamide, low-dose furosemide and hydrochlorothiazide treatment all resulted in similar decreases in body weight suggesting that the antihypertensive effect of indapamide occurs through a mechanism independent of contraction of extracellular fluid volume. Intravenous indapamide at doses of 0.3, 1.0 and 3.0 mg/kg caused progressive increases in sodium, potassium and chloride excretion when urine losses were replaced by isotonic saline to prevent extracellular fluid volume contraction. Only at 3.0 mg/kg did plasma potassium decrease significantly (2.92 +/- 0.03 to 2.69 +/- 0.05 mmol/l; p less than 0.05). Neither glomerular filtration rate (GFR) nor renal blood flow (flowmeter) decreased in a dose-related manner; however, effective renal plasma flow assessed by para-aminohippurate clearance did decrease about 15% at the highest dose (p less than 0.05). Proximal re-collection micropuncture studies demonstrated decreased proximal reabsorption. Cortical diluting segment reabsorption was decreased, but CNa + CH2O/GFR increased from 7% to 11% (p less than 0.05). These results indicate that, at doses up to 3.0 mg/kg, indapamide causes a natriuresis which is modest and similar to that seen with thiazides. No decrease in GFR or renal blood flow was observed. This drug apparently exerts a natriuretic effect through an inhibition of solute reabsorption in both the proximal nephron and the cortical diluting segment. | lld:pubmed |
| pubmed-article:6617239 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6617239 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6617239 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6617239 | pubmed:issn | 0300-7995 | lld:pubmed |
| pubmed-article:6617239 | pubmed:author | pubmed-author:BurkeT JTJ | lld:pubmed |
| pubmed-article:6617239 | pubmed:author | pubmed-author:EricksonA LAL | lld:pubmed |
| pubmed-article:6617239 | pubmed:author | pubmed-author:WolfP SPS | lld:pubmed |
| pubmed-article:6617239 | pubmed:author | pubmed-author:NoblesE MEM | lld:pubmed |
| pubmed-article:6617239 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6617239 | pubmed:volume | 8 Suppl 3 | lld:pubmed |
| pubmed-article:6617239 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6617239 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6617239 | pubmed:pagination | 25-37 | lld:pubmed |
| pubmed-article:6617239 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6617239 | pubmed:meshHeading | pubmed-meshheading:6617239-... | lld:pubmed |
| pubmed-article:6617239 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6617239 | pubmed:articleTitle | Effect of indapamide on volume-dependent hypertension, renal haemodynamics, solute excretion and proximal nephron fractional reabsorption in the dog. | lld:pubmed |
| pubmed-article:6617239 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6617239 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6617239 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6617239 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
