| pubmed-article:6600840 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6600840 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:6600840 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:6600840 | lifeskim:mentions | umls-concept:C0003242 | lld:lifeskim |
| pubmed-article:6600840 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6600840 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6600840 | pubmed:dateCreated | 1983-4-15 | lld:pubmed |
| pubmed-article:6600840 | pubmed:abstractText | We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response. This response is anti-idiotypic in nature because lymphocytes so primed display accelerated memory responses only when restimulated by autologous lymphoblasts that have been alloactivated against the same HLA-DR antigen. Based on this observation we have postulated that the absence of HLA antibodies in alloimmunized human subjects may be due to the development of autoantibodies that react with the anti-HLA receptors expressed by primed lymphocytes or by anti-HLA antibodies or both. This hypothesis has been confirmed in the present investigations which show that sera from parous women react with autologous T lymphoblasts primed in 5-day mixed lymphocyte culture against their husband-i.e., with lymphoblasts expressing receptors for the immunizing donor. Anti-HLA receptors expressed by T and B lymphocytes seem to share serologic determinants because sera that bind to autologous alloactivated lymphoblasts are also capable of inhibiting the anti-HLA activity of autologous and homologous sera. Auto-anti-idiotypic antibodies inhibit the autologous mixed lymphocyte response to autologous alloactivated lymphoblasts, a phenomenon whose in vivo correlate may reside in autoinhibition of anti-HLA antibody formation and of allograft immunity. Because auto-anti-idiotypic antibodies were found in sera from all parous women tested, the hypothesis that nonresponsiveness to alloantigens exists as a state per se is not likely. The passive transfer of antireceptor (idiotype) immunity by use of antibodies from pregnant women's sera may provide a powerful tool for specific suppression of allograft rejection. | lld:pubmed |
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| pubmed-article:6600840 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6600840 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6600840 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6600840 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6600840 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6600840 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6600840 | pubmed:author | pubmed-author:KunzEE | lld:pubmed |
| pubmed-article:6600840 | pubmed:author | pubmed-author:Suciu-FocaNN | lld:pubmed |
| pubmed-article:6600840 | pubmed:author | pubmed-author:KingD WDW | lld:pubmed |
| pubmed-article:6600840 | pubmed:author | pubmed-author:RohowskyCC | lld:pubmed |
| pubmed-article:6600840 | pubmed:author | pubmed-author:ReedEE | lld:pubmed |
| pubmed-article:6600840 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6600840 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6600840 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6600840 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6600840 | pubmed:pagination | 830-4 | lld:pubmed |
| pubmed-article:6600840 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6600840 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6600840 | pubmed:articleTitle | Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy. | lld:pubmed |
| pubmed-article:6600840 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6600840 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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