| pubmed-article:6547008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0519671 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0398625 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0032120 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C1744681 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0033621 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6547008 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:6547008 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6547008 | pubmed:dateCreated | 1984-6-18 | lld:pubmed |
| pubmed-article:6547008 | pubmed:abstractText | Protein C is a vitamin K dependent protein involved in blood coagulation. A congenital deficiency in protein C antigen - which inherits as an autosomal dominant disorder - has been reported to be associated with a high risk for thrombo-embolic disease at relatively young age. In the present paper we report on the development of a functional assay for plasma protein C. In this assay protein C is adsorbed to Al(OH)3, eluted and activated by thrombin, after which the concentration of the activated protein C is measured with a peptide substrate (S2366). Normal values for protein C activity and protein C antigen were determined in healthy volunteers and patients on stable oral anticoagulant treatment. Protein C activity and antigen levels were compared in 28 patients from 9 different pedigrees with both congenital protein C deficiency and thrombotic disease. Two types of protein C deficiency could be recognized: in type I the deficiency is due to the absence or reduced presence of protein C molecules, while in type II the deficiency is caused by the presence of an abnormal protein C molecule with strongly reduced functional activity. | lld:pubmed |
| pubmed-article:6547008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6547008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6547008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6547008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6547008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6547008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6547008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6547008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6547008 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6547008 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:6547008 | pubmed:author | pubmed-author:BertinaR MRM | lld:pubmed |
| pubmed-article:6547008 | pubmed:author | pubmed-author:BroekmansA... | lld:pubmed |
| pubmed-article:6547008 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:6547008 | pubmed:author | pubmed-author:Krommenhoek-v... | lld:pubmed |
| pubmed-article:6547008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6547008 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:6547008 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:6547008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6547008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6547008 | pubmed:pagination | 1-5 | lld:pubmed |
| pubmed-article:6547008 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:meshHeading | pubmed-meshheading:6547008-... | lld:pubmed |
| pubmed-article:6547008 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6547008 | pubmed:articleTitle | The use of a functional and immunologic assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency. | lld:pubmed |
| pubmed-article:6547008 | pubmed:publicationType | Journal Article | lld:pubmed |
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