| pubmed-article:6538941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C0018792 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C0007412 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C0014294 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C1372804 | lld:lifeskim |
| pubmed-article:6538941 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:6538941 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6538941 | pubmed:dateCreated | 1984-6-14 | lld:pubmed |
| pubmed-article:6538941 | pubmed:abstractText | Leucine-enkephalin (LE) at 10(-8) M reduces the maximum chronotropic response of isolated spontaneously beating rat atria to exogenously added (-)-norepinephrine (NE) by approximately 27%, with no effect on the NE ED50 (1.5 X 10(-7) M) for positive chronotropy. This modulatory effect of LE is completely blocked by addition of 10(-7) M naloxone, and seems to be catecholamine-receptor specific, since the positive chronotropic response to forskolin is unaltered in the presence of LE. Isoproterenol (ISO)-induced positive chronotropy is also attenuated by LE. This effect is markedly dependent on the extracellular calcium concentration: LE actually causes a greater than two-fold enhancement of the positive chronotropic effect of ISO at low (0.5 mM) extracellular calcium concentration. A possible role for enkephalins to modulate catecholamine action on the heart via an alteration of catecholamine-induced inward calcium flux is discussed. | lld:pubmed |
| pubmed-article:6538941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6538941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6538941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6538941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6538941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6538941 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6538941 | pubmed:issn | 0143-4179 | lld:pubmed |
| pubmed-article:6538941 | pubmed:author | pubmed-author:RustJ NJN | lld:pubmed |
| pubmed-article:6538941 | pubmed:author | pubmed-author:EidenL ELE | lld:pubmed |
| pubmed-article:6538941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6538941 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:6538941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6538941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6538941 | pubmed:pagination | 101-8 | lld:pubmed |
| pubmed-article:6538941 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:6538941 | pubmed:meshHeading | pubmed-meshheading:6538941-... | lld:pubmed |
| pubmed-article:6538941 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6538941 | pubmed:articleTitle | Leucine-enkephalin modulation of catecholamine positive chronotropy in rat atria is receptor-specific and calcium-dependent. | lld:pubmed |
| pubmed-article:6538941 | pubmed:publicationType | Journal Article | lld:pubmed |
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