| pubmed-article:6513926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:6513926 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:6513926 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:6513926 | pubmed:dateCreated | 1985-1-31 | lld:pubmed |
| pubmed-article:6513926 | pubmed:abstractText | To examine myc protein products in the wide variety of human tumor cells having alterations of the c-myc locus, we have prepared an antiserum against a synthetic peptide corresponding to the predicted C-terminal sequence of the human c-myc protein. This antiserum (anti-hu-myc 12C) specifically precipitated two proteins of 64 and 67 kilodaltons in quantities ranging from low levels in normal fibroblasts to 10-fold-higher levels in Epstein-Barr virus-immortalized and Burkitt's lymphoma cell lines, to 20- to 60-fold-higher levels in cell lines having amplified c-myc. The p64 and p67 proteins were found to be highly related by partial V8 proteolytic mapping, and both were demonstrated to be encoded by the c-myc oncogene, using hybrid-selected translation of myc-specific RNA. In addition, the p64 protein was specifically precipitated from cells transfected with a translocated c-myc gene. Both p64 and p67 were found to be nuclear phosphoproteins with extremely short half-lives. In tumor cell lines having alterations at the c-myc locus due to amplification or translocation, we observed a significant change in the expression of p64 relative to p67 when compared with normal or Epstein-Bar virus-immortalized cells. | lld:pubmed |
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| pubmed-article:6513926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6513926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6513926 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6513926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6513926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6513926 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6513926 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:6513926 | pubmed:author | pubmed-author:EisenmanR NRN | lld:pubmed |
| pubmed-article:6513926 | pubmed:author | pubmed-author:HannS RSR | lld:pubmed |
| pubmed-article:6513926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6513926 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:6513926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6513926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6513926 | pubmed:pagination | 2486-97 | lld:pubmed |
| pubmed-article:6513926 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6513926 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6513926 | pubmed:articleTitle | Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. | lld:pubmed |
| pubmed-article:6513926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6513926 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6513926 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6513926 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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