| pubmed-article:6447256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:6447256 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6447256 | pubmed:issue | 5773 | lld:pubmed |
| pubmed-article:6447256 | pubmed:dateCreated | 1980-10-27 | lld:pubmed |
| pubmed-article:6447256 | pubmed:abstractText | Cyclosporin A (CS-A) is an unusual endecapeptide isolated from the fungi Cylindrocarpon lucidum Booth and Trichoderma polysporum. It is a potent immunosuppressive drug that prevents rejection of kidney and heart allografts whilst having a low myelotoxicity. Its mode of action is still unclear but its main target appears to be the T lymphocyte. The mixed lymphocyte reaction (MLR) and cell-mediated lymphocytoxicity (CML) used here are generally regarded as in vitro correlates of allograft rejection. Our data show that CS-A is a powerful inhibitor of MLR reactivity, regardless of whether the cells were obtained from normal or presensitized donors; that the CML of lymph node cells is likewise totally inhibited if the drug is added early during cell culture; and that, by contrast, the cytotoxic response of spleen cells from presensitized but not from normal mice is only partially inhibited, even with a tenfold increase in dose. It is therefore suggested that there exists a population of cytotoxic spleen cells that is relatively resistant to the action of this drug. | lld:pubmed |
| pubmed-article:6447256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6447256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6447256 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6447256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6447256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6447256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6447256 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6447256 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6447256 | pubmed:author | pubmed-author:HorsburghTT | lld:pubmed |
| pubmed-article:6447256 | pubmed:author | pubmed-author:BrentLL | lld:pubmed |
| pubmed-article:6447256 | pubmed:author | pubmed-author:WoodPP | lld:pubmed |
| pubmed-article:6447256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6447256 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:6447256 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:6447256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6447256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6447256 | pubmed:pagination | 609-11 | lld:pubmed |
| pubmed-article:6447256 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
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| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:meshHeading | pubmed-meshheading:6447256-... | lld:pubmed |
| pubmed-article:6447256 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6447256 | pubmed:articleTitle | Suppression of in vitro lymphocyte reactivity by cyclosporin A: existence of a population of drug-resistant cytotoxic lymphocytes. | lld:pubmed |
| pubmed-article:6447256 | pubmed:publicationType | Journal Article | lld:pubmed |
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