| pubmed-article:6427979 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C0037380 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C0327518 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C0327519 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C0032177 | lld:lifeskim |
| pubmed-article:6427979 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:6427979 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6427979 | pubmed:dateCreated | 1984-7-2 | lld:pubmed |
| pubmed-article:6427979 | pubmed:abstractText | The platelet aggregation inhibitor purified from Agkistrodon halys snake venom inhibited rabbit platelet aggregations induced by thrombin, sodium arachidonate, collagen or ionophore A-23187. The IC50 was about 11 micrograms/ml in platelet aggregation regardless of which aggregation inducer was used. beta-Mercaptoethanol abolished both the phospholipase A enzymatic and platelet aggregation inhibitory activities of this venom inhibitor. p-Bromophenacyl bromide-treated venom inhibitor lost almost completely its phosphilipase A enzymatic activity, but retained its platelet aggregation inhibitory effect. In the presence of EGTA, the venom inhibitor still showed the same inhibitory activity on thrombin-, sodium arachidonate-, collagen- or ionophore A23187-induced platelet aggregations triggered by successive addition of Ca2+. The activation of platelet phospholipase A and the serotonin release reaction triggered by Ca2+ influx were unaffected by this venom inhibitor. It also inhibited the clot retraction of platelet-rich plasma. It is concluded that the inhibitory effect of the venom inhibitor on platelet aggregation is independent of its phospholipase A enzymatic activity. Its mode of action is different from those of other known platelet inhibitory drugs. This venom inhibitor possibly acts on a common step subsequent to platelet shape change, leading to inhibition of platelet aggregation. | lld:pubmed |
| pubmed-article:6427979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6427979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6427979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6427979 | pubmed:issn | 0041-0101 | lld:pubmed |
| pubmed-article:6427979 | pubmed:author | pubmed-author:HuangT FTF | lld:pubmed |
| pubmed-article:6427979 | pubmed:author | pubmed-author:OuyangCC | lld:pubmed |
| pubmed-article:6427979 | pubmed:author | pubmed-author:UdyD CDC | lld:pubmed |
| pubmed-article:6427979 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6427979 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:6427979 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6427979 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6427979 | pubmed:pagination | 243-51 | lld:pubmed |
| pubmed-article:6427979 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
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| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:meshHeading | pubmed-meshheading:6427979-... | lld:pubmed |
| pubmed-article:6427979 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6427979 | pubmed:articleTitle | Mechanism of action of the platelet aggregation inhibitor purified from Agkistrodon halys (mamushi) snake venom. | lld:pubmed |
| pubmed-article:6427979 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6427979 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6427979 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
