pubmed-article:6418537 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6418537 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
pubmed-article:6418537 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:6418537 | lifeskim:mentions | umls-concept:C0017263 | lld:lifeskim |
pubmed-article:6418537 | lifeskim:mentions | umls-concept:C0439667 | lld:lifeskim |
pubmed-article:6418537 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:6418537 | pubmed:dateCreated | 1984-2-24 | lld:pubmed |
pubmed-article:6418537 | pubmed:abstractText | The genetics of BCG-induced pulmonary granulomatous inflammation (PGI) and splenomegaly was studied by breeding experiments and by the use of BXD recombinant inbred (RI) and allotype-congenic mice. Breeding studies indicated that the genetic control was multifactorial; this observation was confirmed using BXD RI mice. In addition, studies with BXD RI mice suggested that genes linked to the Igh complex influence responsiveness. The influence of the Igh-linked genes was studied further using allotype-congenic mice; SJL mice (Ighb) developed significantly greater PGI than their congenic partner, SJA/9 (Igha). Data from BALB.Igb, CB-20, and BAB-14 mice suggested that Igh-linked genes influencing PGI were a considerable distance from Igh-1. Igh-linked genes that influence BCG-induced splenomegaly were located on the centrometric side of the Igh-1 locus. This was shown by data in which splenomegaly in BALB.Igb and CB-20, but not BAB-14, mice was significantly augmented over BALB/c mice. Further studies are necessary to understand the significance of these observations. | lld:pubmed |
pubmed-article:6418537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6418537 | pubmed:language | eng | lld:pubmed |
pubmed-article:6418537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6418537 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:6418537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6418537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6418537 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6418537 | pubmed:month | Nov | lld:pubmed |
pubmed-article:6418537 | pubmed:issn | 0190-2148 | lld:pubmed |
pubmed-article:6418537 | pubmed:author | pubmed-author:MooreV LVL | lld:pubmed |
pubmed-article:6418537 | pubmed:author | pubmed-author:SchrierD JDJ | lld:pubmed |
pubmed-article:6418537 | pubmed:author | pubmed-author:SternickJ LJL | lld:pubmed |
pubmed-article:6418537 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6418537 | pubmed:volume | 5 | lld:pubmed |
pubmed-article:6418537 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6418537 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6418537 | pubmed:pagination | 217-28 | lld:pubmed |
pubmed-article:6418537 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:6418537 | pubmed:year | 1983 | lld:pubmed |
pubmed-article:6418537 | pubmed:articleTitle | Genetic control of BCG-induced granulomatous inflammation in mice. | lld:pubmed |
pubmed-article:6418537 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6418537 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:6418537 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6418537 | lld:pubmed |