pubmed-article:6327295 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C1522021 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C1518575 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0034677 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:6327295 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
pubmed-article:6327295 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:6327295 | pubmed:dateCreated | 1984-7-9 | lld:pubmed |
pubmed-article:6327295 | pubmed:abstractText | Five unrelated mouse tumours have been shown to carry activated transforming genes using the NIH/3T3 transfection assay. Three of these tumours, a T-cell lymphoma, a fibrosarcoma and a macrophage tumour, were found to carry an activated c-Ki-ras gene. A c-Ha-ras gene was shown to be activated in a myeloid leukaemia and a recently identified member of the 'ras' gene family, N-ras, was found to be activated in a lung carcinoma. The T-cell lymphoma, L5178Y-ES, is a more aggressively growing metastatic variant which arose spontaneously from the parental tumour, L5178Y-E. Although DNA from both parental and variant tumours was shown to transfer a genetic marker to recipient cells equally well, only the metastatic variant carried an activated c-Ki-ras gene detectable by transfection. The altered growth behaviour of the L5178Y-ES cells may therefore be the result of the spontaneous activation of the c-Ki-ras gene after the lymphoma cells had already become tumorigenic. | lld:pubmed |
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pubmed-article:6327295 | pubmed:language | eng | lld:pubmed |
pubmed-article:6327295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6327295 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6327295 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6327295 | pubmed:month | Apr | lld:pubmed |
pubmed-article:6327295 | pubmed:issn | 0261-4189 | lld:pubmed |
pubmed-article:6327295 | pubmed:author | pubmed-author:MarshallC JCJ | lld:pubmed |
pubmed-article:6327295 | pubmed:author | pubmed-author:VousdenK HKH | lld:pubmed |
pubmed-article:6327295 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6327295 | pubmed:volume | 3 | lld:pubmed |
pubmed-article:6327295 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6327295 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6327295 | pubmed:pagination | 913-7 | lld:pubmed |
pubmed-article:6327295 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:6327295 | pubmed:year | 1984 | lld:pubmed |
pubmed-article:6327295 | pubmed:articleTitle | Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. | lld:pubmed |
pubmed-article:6327295 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6327295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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