| pubmed-article:6323752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6323752 | lifeskim:mentions | umls-concept:C0031303 | lld:lifeskim |
| pubmed-article:6323752 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:6323752 | lifeskim:mentions | umls-concept:C0012935 | lld:lifeskim |
| pubmed-article:6323752 | lifeskim:mentions | umls-concept:C0679426 | lld:lifeskim |
| pubmed-article:6323752 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6323752 | pubmed:dateCreated | 1984-5-24 | lld:pubmed |
| pubmed-article:6323752 | pubmed:abstractText | The intracellular presence of a recombinant plasmid containing the intercistronic region between the genes H and A of bacteriophage phi X174 strongly inhibits the conversion of infecting single-stranded phi X DNA to parental replicative-form DNA. Also, transfection with single-stranded or double-stranded phi X174 DNA of spheroplasts from a strain containing such a "reduction" plasmid shows a strong decrease in phage yield. This phenomenon, the phi X reduction effect, was studied in more detail by using the phi X174 packaging system, by which plasmid DNA strands that contain the phi X(+) origin of replication were packaged as single-stranded DNA into phi X phage coats. These "plasmid particles" can transduce phi X-sensitive host cells to the antibiotic resistance coded for by the vector part of the plasmid. The phi X reduction sequence in the resident plasmid strongly affected the efficiency of the transduction process, but only when the transducing plasmid depended on primosome-mediated initiation of DNA synthesis for its conversion to double-stranded DNA. The combination of these results led to a model for the reduction effect in which the phi X reduction sequence interacted with an intracellular component that was present in limiting amounts and that specified the site at which phi X174 replicative-form DNA replication takes place. The phi X reduction sequence functioned as a viral incompatibility element in a way similar to the membrane attachment site model for plasmid incompatibility. In the DNA of bacteriophage G4, a sequence with a similar biological effect on infecting phages was identified. This reduction sequence not only inhibited phage G4 propagation, but also phi X174 infection. | lld:pubmed |
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| pubmed-article:6323752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6323752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6323752 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6323752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6323752 | pubmed:month | May | lld:pubmed |
| pubmed-article:6323752 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:6323752 | pubmed:author | pubmed-author:van ArkelG... | lld:pubmed |
| pubmed-article:6323752 | pubmed:author | pubmed-author:WeisbeekP JPJ | lld:pubmed |
| pubmed-article:6323752 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:6323752 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:6323752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6323752 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:6323752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6323752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6323752 | pubmed:pagination | 533-40 | lld:pubmed |
| pubmed-article:6323752 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6323752 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6323752 | pubmed:articleTitle | Regions of incompatibility in single-stranded DNA bacteriophages phi X174 and G4. | lld:pubmed |
| pubmed-article:6323752 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6323752 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6323752 | lld:pubmed |
