| pubmed-article:6321733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6321733 | lifeskim:mentions | umls-concept:C0007158 | lld:lifeskim |
| pubmed-article:6321733 | lifeskim:mentions | umls-concept:C0012257 | lld:lifeskim |
| pubmed-article:6321733 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6321733 | lifeskim:mentions | umls-concept:C0220922 | lld:lifeskim |
| pubmed-article:6321733 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6321733 | pubmed:dateCreated | 1984-4-24 | lld:pubmed |
| pubmed-article:6321733 | pubmed:abstractText | A series of digitoxigenin glycosides was studied: five with beta-D-sugars varying stepwise in sugar structure from beta-D-digitoxose to beta-D-galactose, including one beta-D/alpha-D pair. I50 values for these glycosides and digitoxigenin were determined with hog kidney Na+, K+-ATPase. These data suggest a major and unexpected role for 4'-OH conformation in the sugar. All the glycosides with an equatorial 4'-OH were more active than the two with the 4'-OH axial [digitoxigenin beta-D-galactoside (6) I50 = 6.45 X 10(-8) M; digitoxigenin 2'-deoxy-alpha-D-ribo-hexopyranoside (alpha-3a) I50 = 9.33 X 10(-8) M; digitoxigenin I50 = 1.17 X 10(-7) M]. Stereochemistry of the 3'-OH had much less of an activity role than that of the 4'-OH, in contrast to existing models of "sugar-site" binding. | lld:pubmed |
| pubmed-article:6321733 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6321733 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6321733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6321733 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6321733 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:KiharaMM | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:AhmedKK | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:FromA HAH | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:FullertonD... | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:RohrerD CDC | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:SimalJJ | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:KitatsujiEE | lld:pubmed |
| pubmed-article:6321733 | pubmed:author | pubmed-author:DeffoTT | lld:pubmed |
| pubmed-article:6321733 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6321733 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:6321733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6321733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6321733 | pubmed:pagination | 256-61 | lld:pubmed |
| pubmed-article:6321733 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:meshHeading | pubmed-meshheading:6321733-... | lld:pubmed |
| pubmed-article:6321733 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6321733 | pubmed:articleTitle | Cardiac glycosides. 1. A systematic study of digitoxigenin D-glycosides. | lld:pubmed |
| pubmed-article:6321733 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6321733 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6321733 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:6321733 | lld:chembl |
