| pubmed-article:6311105 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0009968 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0036140 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0063146 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:6311105 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:6311105 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6311105 | pubmed:dateCreated | 1983-10-8 | lld:pubmed |
| pubmed-article:6311105 | pubmed:abstractText | Copper (Cu2+) ions at physiological concentrations can promote the formation of hydroxyl radical (OH) or a species of equivalent reactivity. The reaction requires H2O2 and a reducing agent. Reduction of Cu2+ can be achieved by superoxide ion generated by a mixture of hypoxanthine and xanthine oxidase or added directly as its potassium salt. Reduction of Cu2+ can also be achieved by ascorbic acid. Hence both O2- -dependent and ascorbate-dependent formation of OH from H2O2 in the presence of Cu2+ can be observed. Only the former reaction is significantly inhibited by superoxide dismutase. The binding of Cu2+ to histidine or albumin at physiological concentrations decreases the formation of OH radicals in free solution in the presence of either ascorbate or an (O2- -generating system. It is suggested that OH is still formed but reacts immediately with the binding molecule. | lld:pubmed |
| pubmed-article:6311105 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6311105 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311105 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6311105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6311105 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6311105 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6311105 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:6311105 | pubmed:author | pubmed-author:HalliwellBB | lld:pubmed |
| pubmed-article:6311105 | pubmed:author | pubmed-author:RowleyD ADA | lld:pubmed |
| pubmed-article:6311105 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6311105 | pubmed:volume | 225 | lld:pubmed |
| pubmed-article:6311105 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6311105 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6311105 | pubmed:pagination | 279-84 | lld:pubmed |
| pubmed-article:6311105 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:6311105 | pubmed:meshHeading | pubmed-meshheading:6311105-... | lld:pubmed |
| pubmed-article:6311105 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6311105 | pubmed:articleTitle | Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction? | lld:pubmed |
| pubmed-article:6311105 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6311105 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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