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pubmed-article:6281743pubmed:abstractTextIntravascular application of heparin causes a significant rise of free and total thyroid hormone concentrations in serum together with a concomitant drop of the TSH-levels. A causal relationship between these two findings has been firmly established by a number of investigators. The decline of TSH concentrations in serum after heparin injection might just be a physiological reaction of the pituitary gland to the heparin-triggered rise of serum thyroid hormone levels. The present investigations demonstrate a diminution of affinity of thyroid hormone receptors of liver cells. This result confirms the hypothesis that the rise of total thyroid hormone in blood is mainly due to a depletion of liver stores of thyroid hormones. In concordance with clinical findings the binding affinity of cellular pituitary thyroid hormone receptors was found to increase.lld:pubmed
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pubmed-article:6281743pubmed:authorpubmed-author:BeyerH KHKlld:pubmed
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pubmed-article:6281743pubmed:volume21lld:pubmed
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pubmed-article:6281743pubmed:pagination36-41lld:pubmed
pubmed-article:6281743pubmed:dateRevised2007-1-12lld:pubmed
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pubmed-article:6281743pubmed:articleTitle[Causative investigations of heparin-induced rise on thyroid hormone serum levels (author's transl)].lld:pubmed
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