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pubmed-article:6277911pubmed:abstractTextA single locus (designated c-fes) in the human genome which exhibits homology to the transformation-specific onc gene (v-fes) of Snyder-Theilen feline sarcoma virus was identified by the Southern blot technique. Recombinant clones containing 16- to 18-kilobase inserts of human DNA including the c-fes locus were constructed. Restriction endonuclease mapping of these clones verified their identity with native human c-fes and demonstrated the presence of at least two sequences in human c-fes interrupting v-fes-homologous regions. The v-fes-homologous locus in the human genome spans about 4 kilobases. The 5'-3' orientation of the c-fes clones with respect to feline sarcoma virus proviral DNA was determined. The region of the human genome that is homologous to v-fes is proximal to the highly reiterated human Alu sequence but not to the highly reiterated human alphoid sequence.lld:pubmed
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pubmed-article:6277911pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:6277911pubmed:articleTitleIsolation and characterization of a human locus homologous to the transforming gene (v-fes) of feline sarcoma virus.lld:pubmed
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