| pubmed-article:6274462 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0004147 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0018318 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0033497 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0039629 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0054040 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:6274462 | lifeskim:mentions | umls-concept:C0599756 | lld:lifeskim |
| pubmed-article:6274462 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6274462 | pubmed:dateCreated | 1982-3-13 | lld:pubmed |
| pubmed-article:6274462 | pubmed:abstractText | 1 Effects of (--)-, (+/-)-, and (+)-propranolol, atenolol, guanethidine, bretylium and tetracaine were studied on relaxation responses of rabbit ileum and contractile responses of rabbit pulmonary artery and guinea-pig vas deferens to electrical nerve stimulation (2 to 50 Hz). 2 In the ileum, inhibition by tetracaine 3.3 x 10(-6) M occurred at high frequencies of stimulation, while bretylium 1.2 x 10(-4) M and guanethidine 2 x 10(-5) M inhibited responses at all frequencies, the latter producing greater inhibition at low frequencies. 3 (+/-)-Propranolol 10(-5) M produced a tetracaine-type inhibition after 1 h and a bretylium-pattern after 2 h in the ilea and pulmonary arteries and a transition from bretylium- to guanethidine-pattern in the vas deferens, while atenolol 2 x 10(-5) to 10(-4) M produced guanethidine-type inhibition in all preparations. 4 (--)-, (+/-)-, and (+)-Propranolol 3 x 10(-6) to 3.3 x 10(-5) M were equipotent in the vas deferens and ileum. However, inhibition by (--)-propranolol 3.3 x 10(-5) M persisted in the ileum, while that by the (+)-isomer was partially restored by washing. 5 (--)- or (+)-Propranolol 3.3 x 10(-5) M or atenolol 2 x 10(-5) M did not inhibit relaxation of the ileum after the bath temperature was maintained at 4 degrees C for 2 h during drug application. 6 In conclusion, propranolol and atenolol both have gradually developing guanethidine-like adrenergic neurone blocking actions. | lld:pubmed |
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| pubmed-article:6274462 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6274462 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6274462 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6274462 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6274462 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6274462 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:6274462 | pubmed:author | pubmed-author:KubaJJ | lld:pubmed |
| pubmed-article:6274462 | pubmed:author | pubmed-author:MisuYY | lld:pubmed |
| pubmed-article:6274462 | pubmed:author | pubmed-author:KaihoMM | lld:pubmed |
| pubmed-article:6274462 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6274462 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:6274462 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6274462 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6274462 | pubmed:pagination | 365-70 | lld:pubmed |
| pubmed-article:6274462 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6274462 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6274462 | pubmed:articleTitle | Comparative studies of (--)-, (+/-)-propranolol, atenolol, guanethidine, bretylium and tetracaine on adrenergic transmission. | lld:pubmed |
| pubmed-article:6274462 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6274462 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6274462 | lld:pubmed |
