| pubmed-article:6222267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C0014563 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C0023607 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C0030135 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:6222267 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:6222267 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6222267 | pubmed:dateCreated | 1983-7-8 | lld:pubmed |
| pubmed-article:6222267 | pubmed:abstractText | Various functions involving the central nervous system can be manipulated by the sequential administration of p-chlorophenylalanine and 5-hydroxytryptophan, compounds which respectively inhibit and restore the synthesis of 5-hydroxytryptamine in the brain. An involvement of 5-hydroxytryptamine in the control of a particular function has been considered established when the effect of p-chlorophenylalanine on that function can be overcome by treatment with 5-hydroxytryptophan. This assumption is not, however, invariably substantiated when the functional consequences of other methods of depleting 5-hydroxytryptamine are considered; studies on the control of the daily surge of luteinizing hormone in oestrogen-treated ovariectomized rats present such a paradox. The surge can be prevented by p-chlorophenylalanine and restored by 5-hydroxytryptophan. Nevertheless, neurotoxin-induced lesions of the 5-hydroxytryptamine projections from the raphe nuclei are compatible with a normal occurrence of the surge. We have therefore examined the effects of p-chlorophenylalanine and 5-hydroxytryptophan on hypothalamic monoamines in oestrogen-treated ovariectomized rats and find that the drugs respectively suppress and elevate the concentration of adrenaline in addition to that of 5-hydroxytryptamine. Phenylethanolamine N-methyltransferase, the enzyme responsible for converting noradrenaline to adrenaline, is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite, p-chlorophenylethylamine. The reciprocal effects of p-chlorophenylalanine and 5-hydroxytryptophan on the concentration of adrenaline are of particular interest since drugs which inhibit adrenaline synthesis can block the luteinizing hormone surge. It is proposed that when the 5-hydroxytryptophan-reversible effects of treatment with p-chlorophenylalanine are not reproduced by other procedures which deplete 5-hydroxytryptamine, the significant action of these compounds may involve adrenaline. | lld:pubmed |
| pubmed-article:6222267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6222267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6222267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6222267 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6222267 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:6222267 | pubmed:author | pubmed-author:MacKinnonP... | lld:pubmed |
| pubmed-article:6222267 | pubmed:author | pubmed-author:GistD HDH | lld:pubmed |
| pubmed-article:6222267 | pubmed:author | pubmed-author:ClementE MEM | lld:pubmed |
| pubmed-article:6222267 | pubmed:author | pubmed-author:WilsonP MPM | lld:pubmed |
| pubmed-article:6222267 | pubmed:author | pubmed-author:CoombsM CMC | lld:pubmed |
| pubmed-article:6222267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6222267 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:6222267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6222267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6222267 | pubmed:pagination | 583-91 | lld:pubmed |
| pubmed-article:6222267 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6222267 | pubmed:meshHeading | pubmed-meshheading:6222267-... | lld:pubmed |
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| pubmed-article:6222267 | pubmed:meshHeading | pubmed-meshheading:6222267-... | lld:pubmed |
| pubmed-article:6222267 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6222267 | pubmed:articleTitle | Possible resolution of a paradox concerning the use of p-chlorophenylalanine and 5-hydroxytryptophan: evidence for a mode of action involving adrenaline in manipulating the surge of luteinizing hormone in rats. | lld:pubmed |
| pubmed-article:6222267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6222267 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6222267 | lld:pubmed |
