| pubmed-article:6206494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C2931688 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1414081 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1414085 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1415941 | lld:lifeskim |
| pubmed-article:6206494 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:6206494 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:6206494 | pubmed:dateCreated | 1984-10-3 | lld:pubmed |
| pubmed-article:6206494 | pubmed:abstractText | Sequential immunoprecipitates show that H-2dm1 mutant cells express a hybrid "H-2D/L" antigen exhibiting determinants normally associated with two different gene products of the parental d haplotype-i.e., the H-2Dd and H-2Ld antigens. The hybrid H-2D/Ldm1 antigen appears to consist of a portion of the NH2-terminal extracellular half of the H-2Dd antigen "fused" to a portion of the COOH-terminal extracellular half of the H-2Ld antigen. This structure is inferred from the reactivity of dm1 antigens with cytotoxic T lymphocytes specific for H-2Ld determinants and with monoclonal antibodies specific for determinants in the structural domains of H-2Ld or H-2Dd. The H-2D/Ldm1 molecule apparently retains all of the third external domain (C2 or alpha 3) and part of the second external domain (C1 or alpha 2) of H-2Ld, but its first external domain (N or alpha 1) derives from H-2Dd. From these findings and from previous peptide mapping studies, we propose that the H-2D/Ldm1 antigen is the product of a hybrid gene that has resulted from an unequal crossover between the parental H-2Dd and H-2Ld genes, leaving the N exon and part of the C1 exon of the H-2Dd gene joined to the H-2Ld gene beginning somewhere within its C1 exon. | lld:pubmed |
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| pubmed-article:6206494 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6206494 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6206494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6206494 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6206494 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6206494 | pubmed:author | pubmed-author:HungEE | lld:pubmed |
| pubmed-article:6206494 | pubmed:author | pubmed-author:SearsD WDW | lld:pubmed |
| pubmed-article:6206494 | pubmed:author | pubmed-author:OzatoKK | lld:pubmed |
| pubmed-article:6206494 | pubmed:author | pubmed-author:BurnsideS SSS | lld:pubmed |
| pubmed-article:6206494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6206494 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6206494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6206494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6206494 | pubmed:pagination | 5204-8 | lld:pubmed |
| pubmed-article:6206494 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6206494 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6206494 | pubmed:articleTitle | A molecular hybrid of the H-2Dd and H-2Ld genes expressed in the dm1 mutant. | lld:pubmed |
| pubmed-article:6206494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6206494 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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