| pubmed-article:6195284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0079004 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0019627 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:6195284 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:6195284 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6195284 | pubmed:dateCreated | 1983-12-17 | lld:pubmed |
| pubmed-article:6195284 | pubmed:abstractText | A cloned, trinitrophenyl (TNP)-specific helper T cell line (TCL), termed E-11, has been established in long-term, interleukin 2-dependent culture and used to study human T helper (Th)-B cell collaboration. Co-culture of E-11 with TNP-modified, but not unmodified or FITC-modified, autologous B cells results in a vigorous, polyclonally plaque-forming cell (PFC) response. E-11 helper activity is not constitutive, but requires antigen-specific, major histocompatibility complex-restricted activation of the TCL cells by interaction with TNP-modified autologous or DR 5+ allogeneic macrophages. Using B cell subsets isolated by discontinuous density gradient cengrifugation as responder populations, we determined that E-11 activates B cell subsets via two distinct mechanisms: (a) E-11 polyclonally activates large B cells in an unrestricted and nonspecific manner; and (b) E-11 preferentially induces a PFC response by TNP-modified small B cells. These results suggest that the large B cell subset is activated by helper signals generated during the Th-antigen-presenting cell interaction, while small B cells require an additional stimulus that is provided by antigen-specific Th-B cell contact. | lld:pubmed |
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| pubmed-article:6195284 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6195284 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6195284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6195284 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6195284 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6195284 | pubmed:author | pubmed-author:FriedmanS MSM | lld:pubmed |
| pubmed-article:6195284 | pubmed:author | pubmed-author:PrincipatoM... | lld:pubmed |
| pubmed-article:6195284 | pubmed:author | pubmed-author:ThompsonG SGS | lld:pubmed |
| pubmed-article:6195284 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6195284 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6195284 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:6195284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6195284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6195284 | pubmed:pagination | 1444-58 | lld:pubmed |
| pubmed-article:6195284 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6195284 | pubmed:meshHeading | pubmed-meshheading:6195284-... | lld:pubmed |
| pubmed-article:6195284 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6195284 | pubmed:articleTitle | A cloned major histocompatibility complex-restricted trinitrophenyl-reactive human helper T cell line that activates B cell subsets via two distinct pathways. | lld:pubmed |
| pubmed-article:6195284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6195284 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6195284 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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