| pubmed-article:6192344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C0206434 | lld:lifeskim |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C1446680 | lld:lifeskim |
| pubmed-article:6192344 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:6192344 | pubmed:issue | 5925 | lld:pubmed |
| pubmed-article:6192344 | pubmed:dateCreated | 1983-9-20 | lld:pubmed |
| pubmed-article:6192344 | pubmed:abstractText | The three serotypes of poliovirus are members of the picornaviradae, a group of viruses which cause a variety of diseases of considerable importance in man and animals. We have previously used antigenic mutants resistant to neutralizing monoclonal antibodies to identify a single antigenic site for the neutralization of poliovirus type 3 (ref. 1). Evidence based on oligonucleotide mapping suggested that this site corresponded largely to one physicochemical region of the capsid protein viral polypeptide 1 (VP1). We now present conclusive evidence that most of the mutations conferring resistance to neutralization are confined to an eight-amino acid region of VP1, specified by a sequence of viral RNA 277-300 bases from the start of the region coding for VP1. These data strongly suggest that this small region constitutes a major antigenic site involved in virus neutralization and they provide the most detailed information currently available on the antigenic site of a human virus. | lld:pubmed |
| pubmed-article:6192344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6192344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6192344 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6192344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6192344 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6192344 | pubmed:author | pubmed-author:EvansD MDM | lld:pubmed |
| pubmed-article:6192344 | pubmed:author | pubmed-author:MinorP DPD | lld:pubmed |
| pubmed-article:6192344 | pubmed:author | pubmed-author:AlmondJ WJW | lld:pubmed |
| pubmed-article:6192344 | pubmed:author | pubmed-author:SchildG SGS | lld:pubmed |
| pubmed-article:6192344 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6192344 | pubmed:volume | 304 | lld:pubmed |
| pubmed-article:6192344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6192344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6192344 | pubmed:pagination | 459-62 | lld:pubmed |
| pubmed-article:6192344 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6192344 | pubmed:meshHeading | pubmed-meshheading:6192344-... | lld:pubmed |
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| pubmed-article:6192344 | pubmed:meshHeading | pubmed-meshheading:6192344-... | lld:pubmed |
| pubmed-article:6192344 | pubmed:articleTitle | Critical role of an eight-amino acid sequence of VP1 in neutralization of poliovirus type 3. | lld:pubmed |
| pubmed-article:6192344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6192344 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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