| pubmed-article:6181611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C1882623 | lld:lifeskim |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C0684321 | lld:lifeskim |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:6181611 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6181611 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6181611 | pubmed:dateCreated | 1982-12-2 | lld:pubmed |
| pubmed-article:6181611 | pubmed:abstractText | Daily oral treatment with retinoic acid (100 mg/kg bodyweight) induced regression of a transplantable rat chondrosarcoma. In a previous biochemical investigation we have shown that the tissue breakdown is preceded by the loss of proteoglycan. The present study describes the histological changes induced by retinoic acid. A decrease in the intensity of metachromatic staining with toluidine blue was noted already after 1 day and the discoloration was almost complete after 4 days correlating with the loss of proteoglycan. Especially in the perichondrium there was a rapid proliferation of fibroblasts and monocytes. Osteoclast-like cells were missing, but tumor nodules were eroded and split up by penetrating perichondrium. After 4 days of treatment larger necrotic areas were found, initially in the center of tumor nodules only. In other areas the majority of tumorous chondroblasts survived. Tumor nodules appeared partly mesenchyma-like with some fibroblast-like cells suggesting a dedifferentiation of chondroblasts by retinoic acid. we believe that tumor regression induced by retinoic acid involved proteoglycan degradation by chondroblasts themselves and chondroclast-like activity of monocytes and fibroblasts. | lld:pubmed |
| pubmed-article:6181611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6181611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6181611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6181611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6181611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6181611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6181611 | pubmed:issn | 0340-1227 | lld:pubmed |
| pubmed-article:6181611 | pubmed:author | pubmed-author:KistlerAA | lld:pubmed |
| pubmed-article:6181611 | pubmed:author | pubmed-author:EttlinRR | lld:pubmed |
| pubmed-article:6181611 | pubmed:author | pubmed-author:GallaJJ | lld:pubmed |
| pubmed-article:6181611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6181611 | pubmed:volume | 396 | lld:pubmed |
| pubmed-article:6181611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6181611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6181611 | pubmed:pagination | 1-8 | lld:pubmed |
| pubmed-article:6181611 | pubmed:dateRevised | 2008-2-20 | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:meshHeading | pubmed-meshheading:6181611-... | lld:pubmed |
| pubmed-article:6181611 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6181611 | pubmed:articleTitle | Histological changes during regression induced by retinoic acid in a transplantable rat chondrosarcoma. | lld:pubmed |
| pubmed-article:6181611 | pubmed:publicationType | Journal Article | lld:pubmed |
