| pubmed-article:6171779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6171779 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:6171779 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:6171779 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6171779 | lifeskim:mentions | umls-concept:C0733470 | lld:lifeskim |
| pubmed-article:6171779 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:6171779 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:6171779 | pubmed:dateCreated | 1982-2-12 | lld:pubmed |
| pubmed-article:6171779 | pubmed:abstractText | Four hybrid human leukocyte interferon (LeIF or IFN-alpha) genes have been constructed by in vitro recombination of LeIF-A (IFN-alpha 2) and LeIF-D (IFN-alpha 1) genes at common restriction endonuclease sites located within their coding regions. These hybrid genes have been expressed in E. coli under trp promoter control. The interferons produced [LeIF-AD (BglII), -AD (PvuII), -DA (BglII), -DA (PvuII)] have antiviral properties distinct from the parental molecules LeIF-A and -D, varying considerably in their abilities to inhibit plaque formation by different viruses in a range of mammalian cells. All six of the cloned LeIFs exhibit the heat stability, pH 2 stability and antigenic specificity of natural leukocyte interferons. | lld:pubmed |
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| pubmed-article:6171779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6171779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6171779 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6171779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6171779 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6171779 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:WareM CMC | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:GrafP DPD | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:StebbingNN | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:GoeddelD VDV | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:ShepardH MHM | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:LeungDD | lld:pubmed |
| pubmed-article:6171779 | pubmed:author | pubmed-author:AppersonSS | lld:pubmed |
| pubmed-article:6171779 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6171779 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:6171779 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:6171779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6171779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6171779 | pubmed:pagination | 6153-66 | lld:pubmed |
| pubmed-article:6171779 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6171779 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6171779 | pubmed:articleTitle | Antiviral activities of hybrids of two major human leukocyte interferons. | lld:pubmed |
| pubmed-article:6171779 | pubmed:publicationType | Journal Article | lld:pubmed |
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