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pubmed-article:6144765pubmed:abstractTextThe influence of smoking an alpha 1-acid glycoprotein (alpha 1-AGP) and serum albumin concentrations and the protein binding of phenytoin and propranolol in healthy volunteers was investigated. alpha 1-AGP concentrations were found to be statistically different (P less than 0.05) in the smokers (mean = 84.3 mg dl-1) versus non-smokers (mean = 62.8 mg dl-1). There was a trend for lower serum albumin concentrations and lower fraction unbound of propranolol in the smokers. Smoking did not affect the protein binding of phenytoin.lld:pubmed
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pubmed-article:6144765pubmed:articleTitleInfluence of smoking on serum protein composition and the protein binding of drugs.lld:pubmed
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