| pubmed-article:6142847 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6142847 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:6142847 | lifeskim:mentions | umls-concept:C0460148 | lld:lifeskim |
| pubmed-article:6142847 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:6142847 | lifeskim:mentions | umls-concept:C1268086 | lld:lifeskim |
| pubmed-article:6142847 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:6142847 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6142847 | pubmed:dateCreated | 1984-5-16 | lld:pubmed |
| pubmed-article:6142847 | pubmed:abstractText | Direct comparison of drug interaction with intraocular relative to extraocular beta-adrenergic receptors was used to test the hypothesis that the receptors in ocular tissues are of the beta 2-subtype. Potencies for the displacement of 3H-dihydroalprenolol radioligand binding to membranes obtained from rabbit-iris ciliary bodies by beta-adrenoceptor agonists was in the order: isoproterenol greater than or equal to epinephrine greater than salbutamol greater than terbutaline greater than tazolol greater than norepinephrine. Similar radioligand displacement by beta-adrenoceptor antagonists was in the order of potency: alprenolol greater than or equal to bupranolol = oxprenolol = timolol = propranolol greater than ICI 118,551 = IPS 339 much greater than betaxolol greater than metoprolol. Finally, for the above beta-adrenoceptor antagonists, a highly significant correlation was obtained for displacement of radioligand to ocular tissues (pKi values) relative to antagonism (pA2 values) of isoproterenol-induced guinea-pig tracheal relaxation but not guinea-pig atrial chronotropic effects. Consequently, the above three observations reinforce the notion that rabbit-iris ciliary bodies contain beta-adrenergic receptors predominantly of the beta 2-subtype. | lld:pubmed |
| pubmed-article:6142847 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6142847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6142847 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6142847 | pubmed:issn | 0721-832X | lld:pubmed |
| pubmed-article:6142847 | pubmed:author | pubmed-author:GrossD MDM | lld:pubmed |
| pubmed-article:6142847 | pubmed:author | pubmed-author:ShareN NNN | lld:pubmed |
| pubmed-article:6142847 | pubmed:author | pubmed-author:SchmittC JCJ | lld:pubmed |
| pubmed-article:6142847 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6142847 | pubmed:volume | 221 | lld:pubmed |
| pubmed-article:6142847 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6142847 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6142847 | pubmed:pagination | 167-70 | lld:pubmed |
| pubmed-article:6142847 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
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| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
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| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:meshHeading | pubmed-meshheading:6142847-... | lld:pubmed |
| pubmed-article:6142847 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6142847 | pubmed:articleTitle | Beta-adrenergic receptor subtypes in iris-ciliary body of rabbits. | lld:pubmed |
| pubmed-article:6142847 | pubmed:publicationType | Journal Article | lld:pubmed |
