| pubmed-article:6092624 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6092624 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:6092624 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:6092624 | lifeskim:mentions | umls-concept:C0037189 | lld:lifeskim |
| pubmed-article:6092624 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:6092624 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:6092624 | pubmed:dateCreated | 1984-12-10 | lld:pubmed |
| pubmed-article:6092624 | pubmed:abstractText | The ionic nature of the pace-maker current (delta Ip, If, Ih) was investigated in rabbit sino-atrial node using a single sucrose-gap voltage-clamp technique. The pace-maker current was activated by hyperpolarizing clamp steps negative to -50 mV and the pace-maker potential was activated by an action potential or a depolarizing clamp step. Neither pace-maker current nor pace-maker potential were altered by addition of tetrodotoxin, but a tetrodotoxin-sensitive channel could be activated in sino-atrial nodal strips following hyperpolarizing clamp steps. Ca2+-channel blockers did not affect the voltage dependence of delta Ip or the maximum diastolic potential (m.d.p.) significantly. Removal of Ca2+ did not affect the pace-maker current at clamp potentials near the pace-maker potential range (-60 to -80 mV), but it did reduce the potential dependence of the m.d.p. Removal of Na+ suppressed completely the pace-maker current and hyperpolarized the membrane. Removal of Na+ also increased membrane conductance, most likely through an increase in resting K+ permeability. Low concentration of Cs+ (less than 5 mM), but not Ba2+ or tetraethylammonium, markedly suppressed activation delta Ip and reduced the rate of pacing slightly. Cs+ also decreased the membrane conductance and hyperpolarized the membrane. In 50% of experiments designed to determine contribution of IK to pace-maker current, a double-pulse procedure revealed a time-dependent component of delta Ip which reversed near the K+ equilibrium potential, EK. Release of depolarizing or hyperpolarizing test clamps was followed by pace-maker potentials, the magnitudes of which were dependent on the test-clamp potential. The m.d.p. approached values near EK following depolarizing clamps and near -45 mV following hyperpolarizing clamps. The results suggest that delta Ip is carried primarily by Na+ and is blocked by Cs+. It is likely, however, that Ca2+ alters the rate of pacing not only through its contribution to the Isi system, but also through activation of a K+ conductance. | lld:pubmed |
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| pubmed-article:6092624 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6092624 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6092624 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6092624 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6092624 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6092624 | pubmed:author | pubmed-author:MoradMM | lld:pubmed |
| pubmed-article:6092624 | pubmed:author | pubmed-author:MaylieJJ | lld:pubmed |
| pubmed-article:6092624 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6092624 | pubmed:volume | 355 | lld:pubmed |
| pubmed-article:6092624 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6092624 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6092624 | pubmed:pagination | 215-35 | lld:pubmed |
| pubmed-article:6092624 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6092624 | pubmed:meshHeading | pubmed-meshheading:6092624-... | lld:pubmed |
| pubmed-article:6092624 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6092624 | pubmed:articleTitle | Ionic currents responsible for the generation of pace-maker current in the rabbit sino-atrial node. | lld:pubmed |
| pubmed-article:6092624 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6092624 | pubmed:publicationType | In Vitro | lld:pubmed |
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