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| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:6084592 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:6084592 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:6084592 | pubmed:dateCreated | 1985-3-28 | lld:pubmed |
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| pubmed-article:6084592 | pubmed:abstractText | The nucleotide sequences of the variable region genes expressed in the heavy and light chains of six isogeneic anti-idiotope antibodies recognizing idiotopes on two closely related antibodies with specificity for the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP) were determined. In two independently derived anti-idiotope cell lines the same or strongly homologous V kappa, VH and D region genes had originally been rearranged. The two lines express long and partly homologous N sequences (presumed to be not of germ line origin) at the border of D, resulting in CDR3s of unusual length. An unusually long CDR3, partly encoded by N sequences, is also present in the heavy chain of a third anti-idiotope antibody. The VH regions of the three remaining anti-idiotope antibodies originate from a single VH gene which belongs to the same VH group as the VH genes expressed in the other anti-idiotopes. Two of these antibodies, expressing similar V, D and J elements, had been isolated from the same mouse and appear to have diverged from the same B cell precursor by at least two rounds of somatic mutation. Somatic point mutations have occurred in most, if not all anti-idiotope V region sequences. In two instances somatic mutations in J increase the structural homology between anti-idiotopes. The anti-idiotypic response in this system is thus genetically restricted and may depend upon the selection of non-germ line sequences, suggesting an explanation for the low frequency at which anti-idiotope antibodies are expressed in this system. | lld:pubmed |
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| pubmed-article:6084592 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6084592 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6084592 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6084592 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6084592 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6084592 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:6084592 | pubmed:author | pubmed-author:RajewskyKK | lld:pubmed |
| pubmed-article:6084592 | pubmed:author | pubmed-author:SablitzkyFF | lld:pubmed |
| pubmed-article:6084592 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6084592 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6084592 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:6084592 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6084592 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6084592 | pubmed:pagination | 3005-12 | lld:pubmed |
| pubmed-article:6084592 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6084592 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6084592 | pubmed:articleTitle | Molecular basis of an isogeneic anti-idiotypic response. | lld:pubmed |
| pubmed-article:6084592 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6084592 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6084592 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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