| pubmed-article:6034113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6034113 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:6034113 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:6034113 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6034113 | pubmed:dateCreated | 1967-10-12 | lld:pubmed |
| pubmed-article:6034113 | pubmed:abstractText | 1. The 24 hourly excretion of pyruvate and glucose has been measured in alloxan-diabetic rats.2. The animals were allowed a 6-day control period before being injected with alloxan (I.V. 50 mg/kg body weight). The diabetes was treated by daily injections of insulin for a period of 6 days from the 7th to the 12th day following the alloxan injection.3. The pyruvate excretion increased more than 5-fold following the induction of diabetes, the values being 189 +/- 130 (S.D.) mug/24 hr in the control period rising to an average of 1002 +/- 664 (S.D.) mug/24 hr over the first 6 days of diabetes. The administration of insulin over the second 6-day period of diabetes caused the pyruvate excretion to decrease-though not significantly. Upon the withdrawal of the insulin treatment the pyruvate excretion increased significantly from 785 +/- 315 (S.D.) mug/24 hr to 2105 +/- 679 (S.D.) mug/24 hr, measured over a 5-day period. The final period of pyruvate excretion was significantly greater than the excretion over the first diabetic period.4. The glucose excretion during the initial diabetic period was 6.75 +/- 2.64 (S.D.) g/24 hr. The administration of insulin caused a 42% decrease in glucose excretion compared to a decrease of 22% for the pyruvate. The withdrawal of insulin caused the glucose excretion to increase by 149% while the pyruvate excretion increased by 157%.5. Diabetes was also induced temporarily by injections of anti-insulin serum and diazoxide. In each case significant glycosuria and hyperpyruvaturia were produced.6. The possible causes of the hyperpyruvaturia in diabetes are discussed. | lld:pubmed |
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| pubmed-article:6034113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6034113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6034113 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6034113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6034113 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6034113 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6034113 | pubmed:author | pubmed-author:TomlinsonR... | lld:pubmed |
| pubmed-article:6034113 | pubmed:author | pubmed-author:AndersonJJ | lld:pubmed |
| pubmed-article:6034113 | pubmed:author | pubmed-author:CoulsonRR | lld:pubmed |
| pubmed-article:6034113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6034113 | pubmed:volume | 189 | lld:pubmed |
| pubmed-article:6034113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6034113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6034113 | pubmed:pagination | 237-46 | lld:pubmed |
| pubmed-article:6034113 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6034113 | pubmed:meshHeading | pubmed-meshheading:6034113-... | lld:pubmed |
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| pubmed-article:6034113 | pubmed:meshHeading | pubmed-meshheading:6034113-... | lld:pubmed |
| pubmed-article:6034113 | pubmed:year | 1967 | lld:pubmed |
| pubmed-article:6034113 | pubmed:articleTitle | Hyperpyruvaturia in experimental diabetes. | lld:pubmed |
| pubmed-article:6034113 | pubmed:publicationType | Journal Article | lld:pubmed |
