| pubmed-article:5797780 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0023660 | lld:lifeskim |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:5797780 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:5797780 | pubmed:issue | 5667 | lld:pubmed |
| pubmed-article:5797780 | pubmed:dateCreated | 1969-9-9 | lld:pubmed |
| pubmed-article:5797780 | pubmed:abstractText | Intravenous lignocaine (1 mg./kg. body weight) was found to produce insignificant haemodynamic changes, and in particular no reduction in myocardial contractility. A rate of 2 mg./minute infused intravenously is suggested for therapeutic purposes.In anaesthetized dogs an infusion of 13.5 mg./minute caused moderate haemodynamic depression and a maximum plasma level of 7 mug./ml. Massive injections of 200 and 400 mg. of lignocaine produced a maximum plasma level of 13.8 and 27.8 mug./ml., respectively, and in the latter failure of myocardial contraction in the presence of a normal E.C.G. ensued ("pump failure"). Lignocaine appears to alter the uptake of calcium by myocardial sarcoplasmic reticulum, and this may explain the negative inotropic effect of large doses. | lld:pubmed |
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| pubmed-article:5797780 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:5797780 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:5797780 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:5797780 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:5797780 | pubmed:issn | 0007-1447 | lld:pubmed |
| pubmed-article:5797780 | pubmed:author | pubmed-author:BinnionP FPF | lld:pubmed |
| pubmed-article:5797780 | pubmed:author | pubmed-author:MurtaghGG | lld:pubmed |
| pubmed-article:5797780 | pubmed:author | pubmed-author:PollockA MAM | lld:pubmed |
| pubmed-article:5797780 | pubmed:author | pubmed-author:FletcherEE | lld:pubmed |
| pubmed-article:5797780 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:5797780 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:5797780 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:5797780 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:5797780 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:5797780 | pubmed:pagination | 390-2 | lld:pubmed |
| pubmed-article:5797780 | pubmed:dateRevised | 2010-10-26 | lld:pubmed |
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| pubmed-article:5797780 | pubmed:year | 1969 | lld:pubmed |
| pubmed-article:5797780 | pubmed:articleTitle | Relation between plasma lignocaine levels and induced haemodynamic changes. | lld:pubmed |
| pubmed-article:5797780 | pubmed:publicationType | Journal Article | lld:pubmed |
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