| pubmed-article:541734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0041249 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:541734 | lifeskim:mentions | umls-concept:C1709630 | lld:lifeskim |
| pubmed-article:541734 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:541734 | pubmed:dateCreated | 1980-6-16 | lld:pubmed |
| pubmed-article:541734 | pubmed:abstractText | In animal studies, DL-[carboxyl-14C]tryptophan [DL-Try(C-14)] showed a high specificity for the pancreas, which suggested the potential of DL-[carboxyl-11C]tryptophan [DL-Try(C-11)] for clinical pancreatic inaging. The blood clearance and tissue uptake of the amino acid were very rapid, and no carrier effect was observed through a dose of 5 mg/kg. None of three transplanted hamster pancreatic adenocarcinomas that we studied showed a selective uptake of DL-Try(C-14) by the tumor, and none of the three enzymatic regimens investigated gave significant enhancement of the pancreatic specificity. Commercial L-Try(C-14) gave slightly better pancreatic specificity than the analogous racemic compound but without enough improvement to warrant attempts at optical resolution. DL-Try(C-11) was synthesized in amounts up to 325 mCi using a rapid, high-temperature, high-pressure modification of the Bücherer-Strecker amino acid synthesis. Yields ranged from 30--60%, and a total of 40 min was required for synthesis and chromatographic purification. DL-Try(C-11) thus appears to have significant potential as a clinical pancreas-imaging agent, particularly when used in conjunction with positron computerized transaxial tomography. | lld:pubmed |
| pubmed-article:541734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:541734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:541734 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:541734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:541734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:541734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:541734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:541734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:541734 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:541734 | pubmed:issn | 0161-5505 | lld:pubmed |
| pubmed-article:541734 | pubmed:author | pubmed-author:HayesR LRL | lld:pubmed |
| pubmed-article:541734 | pubmed:author | pubmed-author:SunT TTT | lld:pubmed |
| pubmed-article:541734 | pubmed:author | pubmed-author:ByrdB LBL | lld:pubmed |
| pubmed-article:541734 | pubmed:author | pubmed-author:WashburnL CLC | lld:pubmed |
| pubmed-article:541734 | pubmed:author | pubmed-author:ButlerT ATA | lld:pubmed |
| pubmed-article:541734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:541734 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:541734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:541734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:541734 | pubmed:pagination | 857-64 | lld:pubmed |
| pubmed-article:541734 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:541734 | pubmed:meshHeading | pubmed-meshheading:541734-N... | lld:pubmed |
| pubmed-article:541734 | pubmed:meshHeading | pubmed-meshheading:541734-I... | lld:pubmed |
| pubmed-article:541734 | pubmed:meshHeading | pubmed-meshheading:541734-T... | lld:pubmed |
| pubmed-article:541734 | pubmed:meshHeading | pubmed-meshheading:541734-S... | lld:pubmed |
| pubmed-article:541734 | pubmed:meshHeading | pubmed-meshheading:541734-M... | lld:pubmed |
| pubmed-article:541734 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:541734 | pubmed:articleTitle | DL-[Carboxyl-11C]tryptophan, a potential agent for pancreatic imaging; production and preclinical investigations. | lld:pubmed |
| pubmed-article:541734 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:541734 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:541734 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
