| pubmed-article:4747918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C0043481 | lld:lifeskim |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:4747918 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:4747918 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4747918 | pubmed:dateCreated | 1974-1-4 | lld:pubmed |
| pubmed-article:4747918 | pubmed:abstractText | The requirement for Zn(++) in DNA replication by phytohemagglutinin-stimulated human lymphocytes was studied. When 6 microM o-phenanthroline, a chelator with a high affinity for Zn(++), is added to cultures of stimulated lymphocytes a nearly complete inhibition of thymidine incorporation results within a few hours. In contrast, the incorporation of uridine is only slightly reduced and the incorporation of leucine is unaffected. m-Phenanthroline, a nonchelating analogue, does not alter the rate of thymidine incorporation even when present in 10-fold greater amounts than o-phenanthroline. The inhibition of thymidine incorporation by o-phenanthroline could be entirely reversed by the addition of Zn(++) to the cultures, or could be prevented by the prior addition of either Zn(++) or Ni(++). All other divalent cations tested were incapable of reversing the o-phenanthroline inhibition of thymidine incorporation. | lld:pubmed |
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| pubmed-article:4747918 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4747918 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4747918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4747918 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:4747918 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:4747918 | pubmed:author | pubmed-author:LoebL ALA | lld:pubmed |
| pubmed-article:4747918 | pubmed:author | pubmed-author:WilliamsR ORO | lld:pubmed |
| pubmed-article:4747918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4747918 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:4747918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4747918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4747918 | pubmed:pagination | 594-601 | lld:pubmed |
| pubmed-article:4747918 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:4747918 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4747918 | pubmed:articleTitle | Zinc requirement for DNA replication in stimulated human lymphocytes. | lld:pubmed |
| pubmed-article:4747918 | pubmed:publicationType | Journal Article | lld:pubmed |
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