| pubmed-article:4724590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4724590 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:4724590 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:4724590 | lifeskim:mentions | umls-concept:C0010405 | lld:lifeskim |
| pubmed-article:4724590 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:4724590 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4724590 | pubmed:dateCreated | 1973-10-14 | lld:pubmed |
| pubmed-article:4724590 | pubmed:abstractText | 1. When human erythrocytes, suspended in iso-osmotic sucrose containing CaCl(2), are stored at 3 degrees C, Ca(2+) influx into the cells occurs. Simultaneously, efflux of K(+), Na(+), Cl(-) and water takes place and cell volume diminishes. 2. The extent of Ca(2+) influx increases with duration of cold storage and with increasing concentration of Ca(2+) in the suspending medium. 3. Erythrocytes that have been thus loaded with Ca(2+) exhibit Ca(2+) efflux against a concentration gradient when subsequently incubated at 37 degrees C. 4. Ca(2+) influx likewise occurs when the sucrose of the medium is replaced by iso-osmotic solutions of other non-ionized compounds. 5. Replacement of sucrose by iso-osmotic KCl or NaCl greatly diminishes the rate of Ca(2+) influx during cold storage; however, in iso-osmotic choline chloride, Ca(2+) influx is as rapid as in sucrose. 6. Preincubation of erythrocytes in iso-osmotic sucrose at 37 degrees C causes rapid efflux of K(+) and Na(+) and renders the cell membranes highly permeable to Ca(2+) during subsequent cold storage. 7. Preincubation of erythrocytes in iso-osmotic NaCl at 37 degrees C with trypsin or neuraminidase is without effect on the permeability of the membrane towards Ca(2+). 8. The experimental results lead to the conclusion that the main prerequisite for Ca(2+) influx into erythrocytes is the partial depletion of the cells of their univalent cations. | lld:pubmed |
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| pubmed-article:4724590 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4724590 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4724590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4724590 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:4724590 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4724590 | pubmed:author | pubmed-author:LongCC | lld:pubmed |
| pubmed-article:4724590 | pubmed:author | pubmed-author:MouatBB | lld:pubmed |
| pubmed-article:4724590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4724590 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:4724590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4724590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4724590 | pubmed:pagination | 559-70 | lld:pubmed |
| pubmed-article:4724590 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4724590 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4724590 | pubmed:articleTitle | The influx of calcium ions into human erythrocytes during cold storage. | lld:pubmed |
| pubmed-article:4724590 | pubmed:publicationType | Journal Article | lld:pubmed |
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