| pubmed-article:4368822 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0025979 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0010737 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C0425245 | lld:lifeskim |
| pubmed-article:4368822 | lifeskim:mentions | umls-concept:C1519027 | lld:lifeskim |
| pubmed-article:4368822 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4368822 | pubmed:dateCreated | 1974-10-31 | lld:pubmed |
| pubmed-article:4368822 | pubmed:abstractText | Functional and morphologic effects of cytochalasin B on the cultivated macrophage were examined to determine the basis for plasma membrane movements of the type required for endocytosis and/or spreading on a substratum. Inhibition of phagocytosis and changes in cell shape by cytochalasin B exhibited nearly identical dose-response curves requiring 2-5 x 10(-6) M and 1-2 x 10(-5) M cytochalasin B to inhibit these functions by 50% and 100%, respectively. In contrast, hexose transport was ten times more sensitive to the drug requiring 2-3 x 10(-7) M cytochalasin B to achieve 50% inhibition of 2-deoxyglucose uptake. Inhibition of phagocytosis and changes in cell shape could not be explained solely by drug effects on hexose transport. Analysis of serial thin sections showed that cytochalasin B doses inhibitory for hexose transport had no effect on distribution or organization of either of the two subplasmalemmal microfilament types. However, cytochalasin B concentrations (2.0 x 10(-5) M) that inhibited phagocytosis and altered cell shape disorganized and/or disrupted oriented bundles of 40-50-A subplasmalemmal microfilaments, but had no effect on the microfilamentous network. Comparative dose-response studies showing positive correlations among cytochalasin B effects on phagocytosis, changes in cell shape, and alterations in oriented subplasmalemmal microfilament bundles provide additional support for the hypothesis that microfilamentous structures play a role in translocation of plasma membrane required for endocytosis and cell motility. | lld:pubmed |
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| pubmed-article:4368822 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4368822 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4368822 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4368822 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:4368822 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:4368822 | pubmed:author | pubmed-author:ReavenE PEP | lld:pubmed |
| pubmed-article:4368822 | pubmed:author | pubmed-author:AxlineS GSG | lld:pubmed |
| pubmed-article:4368822 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4368822 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:4368822 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4368822 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4368822 | pubmed:pagination | 647-59 | lld:pubmed |
| pubmed-article:4368822 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:4368822 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4368822 | pubmed:articleTitle | Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B. Role of subplasmalemmal microfilaments. | lld:pubmed |
| pubmed-article:4368822 | pubmed:publicationType | Journal Article | lld:pubmed |
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