| pubmed-article:416781 | pubmed:abstractText | The cells of the SA node (SAN) are very resistant to the action of tetrodotoxine (TTX), a drug which. paradoxically, blocks depolarisation of the outer myocardial cells. Injection of TTX into the artery of the SAN brings about asystole; bur regular electrical activity, consisting of a slow wave of 200 to 300 ms duration, can still be picked up by an electrode placed on the SAN. This electrical activity, which can only be picked up over the SAN, and is resistant to TTX but blocked by acetylcholine, is interpretated as being the electrogram of the SAN. After the artery has been washed out by normal saline, the effect of TTX becomes progressively less; under these conditions, all degrees of sino-atrial block can be observed. Arising from a study of the phenomena of capture of the SA and AV nodes, of the effect of artrial stimulation, and of the time relationships between the various electrical events recorded, some hypotheses of the electrophysiology of the SAN and the sino-atrial conduction are put forward. | lld:pubmed |
