| pubmed-article:4091828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C1705480 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0001640 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0031469 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0185112 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:4091828 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:4091828 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4091828 | pubmed:dateCreated | 1986-3-26 | lld:pubmed |
| pubmed-article:4091828 | pubmed:abstractText | A Ca2+-sensitive electrode was used to study net Ca2+-flux changes induced by the administration of phenylephrine, vasopressin and angiotensin to the perfused rat liver. The studies reveal that, although the Ca2+ responses induced by vasopressin and angiotensin are similar, they are quite different from the Ca2+ fluxes induced by phenylephrine. The administration of phenylephrine is accompanied by a stimulation of a net amount of Ca2+ efflux (140 nmol/g of liver). A re-uptake of a similar amount of Ca2+ occurs only after the hormone is removed. In contrast, the administration of vasopressin or angiotensin to livers perfused with 1.3 mM-Ca2+ induces the release of a relatively small amount of Ca2+ (approx. 40 nmol/g of liver) during the first 60 s. This is followed by a much larger amount of Ca2+ uptake (70-140 nmol/g of liver) after 1-2.5 min of hormone administration, and a slow efflux or loss of a similar amount of Ca2+ over a period of 6-8 min. At lower concentrations of perfusate Ca2+ (less than 600 microM) these hormones induce only a net efflux of the ion. These results suggest that at physiological concentrations of extracellular Ca2+ the mechanism by which alpha-adrenergic agonists mobilize cellular Ca2+ is different from that involving vasopressin and angiotensin. It seems that the hormones may have quite diverse effects on Ca2+ transport across the plasma membrane and perhaps organellar membranes in liver. | lld:pubmed |
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| pubmed-article:4091828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4091828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4091828 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4091828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4091828 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:4091828 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4091828 | pubmed:author | pubmed-author:BygraveF LFL | lld:pubmed |
| pubmed-article:4091828 | pubmed:author | pubmed-author:AltinJ GJG | lld:pubmed |
| pubmed-article:4091828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4091828 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:4091828 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:4091828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4091828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4091828 | pubmed:pagination | 911-7 | lld:pubmed |
| pubmed-article:4091828 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4091828 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4091828 | pubmed:articleTitle | The Ca2+-mobilizing actions of vasopressin and angiotensin differ from those of the alpha-adrenergic agonist phenylephrine in the perfused rat liver. | lld:pubmed |
| pubmed-article:4091828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4091828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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