| pubmed-article:40564 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C0003364 | lld:lifeskim |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C0232105 | lld:lifeskim |
| pubmed-article:40564 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:40564 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:40564 | pubmed:dateCreated | 1979-12-20 | lld:pubmed |
| pubmed-article:40564 | pubmed:abstractText | A simple method for the detection of antihypertensive activity in anaesthetised (66 mg/kg i. v. alpha-chloralose and 20 mg/kg i. v. aprobarbital) normotensive rats is described. Dihydralazine (0.5 to 2 mg/kg i. v.) reduced blood pressure dose-dependently but did not provoke the anticipated tachycardia. Clonidine (1 to 8 microgram/kg i.a.), guanethidine (0.5 to 5 mg/kg i.a.) and alpha-methyldopa (2.5 to 10 mg/kg i.a.) reduced blood pressure dose-dependently; the effect of reserpine (0.1 to 1.0 mg/kg i.a) was, however, not dose-dependent. Although all four drugs reduced heart rate, only clonidine and guanethidine did so in a dose-dependent manner. Phentolamine (0.5 to 2 mg/kg i. v.) and propranolol (0.01 to 1 mg/kg i. v.) elicited dose-dependent falls in blood pressure. Whereas phentolamine increased heart-rate slightly, propranolol elicited a bradycardia. It is concluded that the chloralose-aprobarbital anaesthetised rat is a suitable and economical model for the screening of potential antihypertensive agents including beta-adrenoceptor antagonists. However, reflex trachycardia provoked by peripheral vasodilators may not be apparent. | lld:pubmed |
| pubmed-article:40564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:40564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:40564 | pubmed:issn | 0004-4172 | lld:pubmed |
| pubmed-article:40564 | pubmed:author | pubmed-author:ChuDD | lld:pubmed |
| pubmed-article:40564 | pubmed:author | pubmed-author:HofmannAA | lld:pubmed |
| pubmed-article:40564 | pubmed:author | pubmed-author:StürmerEE | lld:pubmed |
| pubmed-article:40564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:40564 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:40564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:40564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:40564 | pubmed:pagination | 2093-7 | lld:pubmed |
| pubmed-article:40564 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:40564 | pubmed:meshHeading | pubmed-meshheading:40564-Di... | lld:pubmed |
| pubmed-article:40564 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:40564 | pubmed:articleTitle | Anaesthetised normotensive rats for the detection of hypotensive activity of a beta-adrenoceptor antagonist and other antihypertensive agents. | lld:pubmed |
| pubmed-article:40564 | pubmed:publicationType | Journal Article | lld:pubmed |
