| pubmed-article:4039530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C0032207 | lld:lifeskim |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:4039530 | lifeskim:mentions | umls-concept:C0599918 | lld:lifeskim |
| pubmed-article:4039530 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:4039530 | pubmed:dateCreated | 1985-6-19 | lld:pubmed |
| pubmed-article:4039530 | pubmed:abstractText | Plasma platinum concentrations were measured in 45 patients receiving 46 courses of cisplatin (DDP) 100-120 mg/m2 and in 21 patients receiving 35-60 mg/m2. Samples were drawn 5 minutes, 24, and 48 hours following completion of the DDP infusion. Nephrotoxicity was defined as a greater than 50% increase in serum creatinine measured at 24 and/or 48 hours when compared to the baseline pretreatment value. In patients receiving DDP 100-120 mg/m2, 5/20 with 5-minute plasma platinum concentrations greater than 6 micrograms/ml developed nephrotoxicity; 0/26 with concentrations less than 6 micrograms/ml became nephrotoxic (p less than 0.05). Concentrations at 24 and 48 hours in toxic and nontoxic patients were similar. Five-minute plasma platinum concentrations in excess of 6 micrograms/ml did not occur in the 21 patients receiving DDP 35-60 mg/m2. Only one of these 21 patients became nephrotoxic. The data suggest that an increased incidence of acute nephrotoxicity is related to high peak plasma platinum concentrations. | lld:pubmed |
| pubmed-article:4039530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4039530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4039530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4039530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4039530 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:4039530 | pubmed:issn | 0277-3732 | lld:pubmed |
| pubmed-article:4039530 | pubmed:author | pubmed-author:YoungC WCW | lld:pubmed |
| pubmed-article:4039530 | pubmed:author | pubmed-author:KelsenD PDP | lld:pubmed |
| pubmed-article:4039530 | pubmed:author | pubmed-author:AlcockNN | lld:pubmed |
| pubmed-article:4039530 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4039530 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:4039530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4039530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4039530 | pubmed:pagination | 77-80 | lld:pubmed |
| pubmed-article:4039530 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:meshHeading | pubmed-meshheading:4039530-... | lld:pubmed |
| pubmed-article:4039530 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4039530 | pubmed:articleTitle | Cisplatin nephrotoxicity. Correlation with plasma platinum concentrations. | lld:pubmed |
| pubmed-article:4039530 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4039530 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:4039530 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:4039530 | lld:pubmed |
