| pubmed-article:4037093 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4037093 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:4037093 | lifeskim:mentions | umls-concept:C0736423 | lld:lifeskim |
| pubmed-article:4037093 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:4037093 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:4037093 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:4037093 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:4037093 | pubmed:dateCreated | 1985-10-10 | lld:pubmed |
| pubmed-article:4037093 | pubmed:abstractText | For the purpose of measuring the intracellular pH (pHi) of the mammalian renal proximal tubule, a liquid membrane pH microelectrode was made using a neutral hydrogen ion-selective carrier. The pHi of the rabbit proximal straight tubule perfused in vitro with a solution containing 25 mM HCO3- was 7.22 +/- 0.03. We noted a value significantly lower than the bath pH of 7.44 +/- 0.02 but significantly higher than the pHi of 6.62 +/- 0.03 predicted for passive H+ distribution. Replacement of luminal Na+ with choline quickly (within 1 min) decreased pHi from 7.25 +/- 0.05 to 7.10 +/- 0.05 (P less than 0.001). This change was reversible when Na+ was added again in the luminal solution. A reduction of luminal Na+ from 20 mM to 0 also reduced pHi from 7.15 +/- 0.06 to 7.04 +/- 0.08, and this pHi reduction was blocked by luminal addition of 1 mM amiloride. However, pHi reduction induced by luminal Na+ removal was not affected by luminal addition of 1 mM SITS. Replacement of bath Na+ with choline also reversibly reduced pHi from 7.27 +/- 0.02 to 7.15 +/- 0.02 (P less than 0.001), but this change was totally blocked by the presence of 1 mM SITS. Accordingly, these data suggest that a Na+-H+ exchanger exists in the luminal membrane of the intact rabbit proximal straight tubule. | lld:pubmed |
| pubmed-article:4037093 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4037093 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4037093 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4037093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:4037093 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4037093 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:4037093 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:4037093 | pubmed:author | pubmed-author:SasakiSS | lld:pubmed |
| pubmed-article:4037093 | pubmed:author | pubmed-author:TakeuchiJJ | lld:pubmed |
| pubmed-article:4037093 | pubmed:author | pubmed-author:ShigaiTT | lld:pubmed |
| pubmed-article:4037093 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4037093 | pubmed:volume | 249 | lld:pubmed |
| pubmed-article:4037093 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4037093 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4037093 | pubmed:pagination | F417-23 | lld:pubmed |
| pubmed-article:4037093 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:4037093 | pubmed:meshHeading | pubmed-meshheading:4037093-... | lld:pubmed |
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| pubmed-article:4037093 | pubmed:meshHeading | pubmed-meshheading:4037093-... | lld:pubmed |
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| pubmed-article:4037093 | pubmed:meshHeading | pubmed-meshheading:4037093-... | lld:pubmed |
| pubmed-article:4037093 | pubmed:meshHeading | pubmed-meshheading:4037093-... | lld:pubmed |
| pubmed-article:4037093 | pubmed:meshHeading | pubmed-meshheading:4037093-... | lld:pubmed |
| pubmed-article:4037093 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4037093 | pubmed:articleTitle | Intracellular pH in the isolated perfused rabbit proximal straight tubule. | lld:pubmed |
| pubmed-article:4037093 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4037093 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:4037093 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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