| pubmed-article:4035689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4035689 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:4035689 | lifeskim:mentions | umls-concept:C0205070 | lld:lifeskim |
| pubmed-article:4035689 | lifeskim:mentions | umls-concept:C0405581 | lld:lifeskim |
| pubmed-article:4035689 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:4035689 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:4035689 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4035689 | pubmed:dateCreated | 1985-10-23 | lld:pubmed |
| pubmed-article:4035689 | pubmed:abstractText | The role of metabolism in 2-methoxyethanol (ME)-induced testicular toxicity has been investigated with Sprague-Dawley rats. Following administration of [14C]ME (250 mg/kg, ip) to a group of animals, there was evidence of testicular damage, identified as depletion of the spermatocyte population. Radioactivity detected in urine over 48 hr after treatment accounted for 55% of the dose. The major urinary metabolites were identified by HPLC and isotope dilution analysis, as methoxyacetic acid (MAA) and methoxyacetylglycine (accounting for 50 to 60% and 18 to 25%, respectively, of urinary radioactivity). Analysis of plasma revealed a rapid conversion of ME to MAA (t1/2 for disappearance of ME = 0.6 +/- 0.03 hr) and gradual clearance of radioactivity (t1/2 = 19.7 +/- 2.3 hr). Pretreatment of animals with pyrazole (400 mg/kg, ip) 1 hr prior to [14C]ME dosing gave complete protection against the testicular toxicity of ME. Radioactivity detected in the urine from the pyrazole-pretreated groups over 48 hr (18%) was significantly lower than in the ME-only group. The major radioactive peak co-chromatographed with ME (30 to 36% of the total urinary radioactivity). MAA and methoxyacetylglycine were not major metabolites. Analysis of plasma revealed almost complete inhibition of the conversion of ME to MAA (t1/2 for disappearance of ME = 42.6 +/- 5.6 hr, clearance of radioactivity t1/2 = 51.0 +/- 7.8 hr). The results demonstrate that metabolic activation is required for 2-methoxyethanol to exert toxicity to the male reproductive system. | lld:pubmed |
| pubmed-article:4035689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4035689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4035689 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4035689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:4035689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4035689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4035689 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:4035689 | pubmed:issn | 0041-008X | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:GrayT JTJ | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:MerkL PLP | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:ThomasL VLV | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:CreasyD MDM | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:WaltersD GDG | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:CookM WMW | lld:pubmed |
| pubmed-article:4035689 | pubmed:author | pubmed-author:FosterP MPM | lld:pubmed |
| pubmed-article:4035689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4035689 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:4035689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4035689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4035689 | pubmed:pagination | 480-9 | lld:pubmed |
| pubmed-article:4035689 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:4035689 | pubmed:meshHeading | pubmed-meshheading:4035689-... | lld:pubmed |
| pubmed-article:4035689 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4035689 | pubmed:articleTitle | The role of metabolism in 2-methoxyethanol-induced testicular toxicity. | lld:pubmed |
| pubmed-article:4035689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4035689 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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