pubmed-article:3995184 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C0008354 | lld:lifeskim |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C0001459 | lld:lifeskim |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C1820288 | lld:lifeskim |
pubmed-article:3995184 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
pubmed-article:3995184 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:3995184 | pubmed:dateCreated | 1985-7-19 | lld:pubmed |
pubmed-article:3995184 | pubmed:abstractText | Two potent inhibitors of mono-adenosine diphosphate (ADP) ribosylation have recently been described and characterized, named p-methoxylbenzylaminodecamethylene guanidine sulfate (MBAMG) and benzylaminododecylguanine hydrochloride (BADGH). We have used these agents to investigate the role of ADP ribosylation in hematopoiesis using long-term marrow cultures. The addition of MBAMG (10(-6) mol/L) or BADGH (5 X 10(-4) mol/L) led to both an inhibition of mature cell production and the development of colony-stimulating factor (CSF-1)-responsive GM-CFC, but had no effect upon spleen colony-forming units (CFU-S) or on progenitor cells which respond to the multilineage stimulating factor present in WEHI-3B cell-conditioned medium. These data indicate that these inhibitors of mono-ADP ribosylation can block the commitment and/or differentiation of stem cells and infers that ADP ribosylation may be of some importance in the hematopoietic process. | lld:pubmed |
pubmed-article:3995184 | pubmed:language | eng | lld:pubmed |
pubmed-article:3995184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3995184 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3995184 | pubmed:month | Jun | lld:pubmed |
pubmed-article:3995184 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:3995184 | pubmed:author | pubmed-author:DexterT MTM | lld:pubmed |
pubmed-article:3995184 | pubmed:author | pubmed-author:HeyworthC MCM | lld:pubmed |
pubmed-article:3995184 | pubmed:author | pubmed-author:WhettonA DAD | lld:pubmed |
pubmed-article:3995184 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3995184 | pubmed:volume | 65 | lld:pubmed |
pubmed-article:3995184 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3995184 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3995184 | pubmed:pagination | 1544-8 | lld:pubmed |
pubmed-article:3995184 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
pubmed-article:3995184 | pubmed:meshHeading | pubmed-meshheading:3995184-... | lld:pubmed |
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pubmed-article:3995184 | pubmed:year | 1985 | lld:pubmed |
pubmed-article:3995184 | pubmed:articleTitle | Inhibitors of cholera toxin-induced adenosine diphosphate ribosylation of membrane-associated proteins block stem cell differentiation. | lld:pubmed |
pubmed-article:3995184 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3995184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3995184 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3995184 | lld:pubmed |