| pubmed-article:3968432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
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| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
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| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C1180059 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0439962 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0009545 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0056204 | lld:lifeskim |
| pubmed-article:3968432 | lifeskim:mentions | umls-concept:C0056205 | lld:lifeskim |
| pubmed-article:3968432 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3968432 | pubmed:dateCreated | 1985-3-20 | lld:pubmed |
| pubmed-article:3968432 | pubmed:abstractText | We have previously shown that multiple complement (C) channels are required for lysis of a nucleated cell in contrast to the single channel requirement for erythrocytes. To further investigate this multichannel requirement for nucleated cells, we examined the stability of terminal C complexes in the plasma membrane of Ehrlich ascites tumor cells. Ehrlich cells bearing C5b-7 or C5b-8 with or without C9 were incubated at 37 degrees C or 0 degree C for various time intervals before converting the remaining complexes to lytic C5b-9 channels. C5b-7, C5b-8, and C5b-8 in the presence of a limited number of C5b-9 complexes disappeared functionally from the plasma membrane at 37 degrees C, with initial half-lives of 31, 20, and 10 min, respectively. Disappearance of these complexes did not occur at 0 degree C, nor did disappearance occur at 37 degrees C when formed on sheep erythrocytes. The fate of C5b-8 complexes on the surface of Ehrlich cells was traced with colloidal gold particles bound to C5 determinants on C5b-8 with the use of immunoelectron microscopy. Colloidal gold could be seen on the cell surface after specific binding to cells carrying C5b-8 sites at 0 degree C. After incubating these cells at 37 degrees C, gold particles were internalized into the cell continuously via endocytic vesicles. It is postulated that terminal C complexes may stimulate or accelerate the removal of these complexes from the cell surface. | lld:pubmed |
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| pubmed-article:3968432 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3968432 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3968432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3968432 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3968432 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3968432 | pubmed:author | pubmed-author:ShinM LML | lld:pubmed |
| pubmed-article:3968432 | pubmed:author | pubmed-author:KoskiC LCL | lld:pubmed |
| pubmed-article:3968432 | pubmed:author | pubmed-author:CarneyD FDF | lld:pubmed |
| pubmed-article:3968432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3968432 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:3968432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3968432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3968432 | pubmed:pagination | 1804-9 | lld:pubmed |
| pubmed-article:3968432 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3968432 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3968432 | pubmed:articleTitle | Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9. | lld:pubmed |
| pubmed-article:3968432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3968432 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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