| pubmed-article:3955184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0025251 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0439810 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0598629 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:3955184 | lifeskim:mentions | umls-concept:C0813981 | lld:lifeskim |
| pubmed-article:3955184 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3955184 | pubmed:dateCreated | 1986-5-7 | lld:pubmed |
| pubmed-article:3955184 | pubmed:abstractText | The total potential energy profile for hydrophobic ion interactions with lipid bilayers can be written as the sum of four terms: the electrical Born, image and dipole contributions, and a neutral energy term. We introduce a specific model for the membrane dipole potential, treating it as a two-dimensional array of point dipoles located near each membrane-water interface. Together with specific theoretical models for the other energy terms, a total potential profile is developed that successfully describes the complete set of thermodynamic parameters for binding and translocation for the two hydrophobic ion structural analogues, tetraphenylphosphonium (TPP+) and tetraphenylboron (TPB-). A reasonable fit to the data is possible if the dipole potential energy has a magnitude of 5.5 + 0.5 kcal/mol (240 + 20 mV), positive inside, and if the neutral energy contribution for TPP+ and TPB- is -7.0 + 1.0 kcal/mol. These results may also have important implications for small ion interactions with membranes and the energetics of charged groups in membrane proteins. | lld:pubmed |
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| pubmed-article:3955184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3955184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3955184 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3955184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3955184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3955184 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3955184 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:3955184 | pubmed:author | pubmed-author:HubbellW LWL | lld:pubmed |
| pubmed-article:3955184 | pubmed:author | pubmed-author:FlewellingR... | lld:pubmed |
| pubmed-article:3955184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3955184 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:3955184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3955184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3955184 | pubmed:pagination | 541-52 | lld:pubmed |
| pubmed-article:3955184 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
| pubmed-article:3955184 | pubmed:meshHeading | pubmed-meshheading:3955184-... | lld:pubmed |
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| pubmed-article:3955184 | pubmed:meshHeading | pubmed-meshheading:3955184-... | lld:pubmed |
| pubmed-article:3955184 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3955184 | pubmed:articleTitle | The membrane dipole potential in a total membrane potential model. Applications to hydrophobic ion interactions with membranes. | lld:pubmed |
| pubmed-article:3955184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3955184 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3955184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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