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pubmed-article:3946421pubmed:abstractTextPolymorphisms of mitochondrially encoded proteins can be detected in human lymphocytes by sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Using an SDS-polyacrylamide 8 M urea system, 17 mitochondrially encoded proteins are distinguishable. Three of these (ME-6, ME-8, and ME-17) were polymorphic among 92 individuals screened, and these polymorphisms are reported here for the first time. With SDS-polyacrylamide electrophoresis without urea, 18 mitochondrial proteins are detectable. One of these (MV-1) varied in two of 31 individuals tested. This polymorphism has been identified previously in HeLa cells. Maternal inheritance of the ME-8 polymorphism was demonstrated by three informative families.lld:pubmed
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pubmed-article:3946421pubmed:articleTitlePolymorphisms of mitochondrially encoded proteins.lld:pubmed
pubmed-article:3946421pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3946421pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed