| pubmed-article:3925975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3925975 | lifeskim:mentions | umls-concept:C0023005 | lld:lifeskim |
| pubmed-article:3925975 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:3925975 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:3925975 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3925975 | pubmed:dateCreated | 1985-9-6 | lld:pubmed |
| pubmed-article:3925975 | pubmed:abstractText | The chemical carcinogen 7,12-dimethylbenz (a) anthracene (DMBA) is a potent carcinogen which, when applied to the skin of BALB/c mice weekly for 7-8 weeks, causes the induction of macroscopically visible skin tumours. We report that DMBA also depletes Langerhans cells (LC) from treated skin; the number of cutaneous LC is reduced by nearly 50% 3 days after the first application of DMBA, and continues to decrease upon further treatment. After 7-8 weeks of DMBA application, while tumours are becoming macroscopically visible, there is a considerably lower LC density in treated skin. Upon cessation of the DMBA treatment, the LC repopulate the skin, returning to control values within 55-64 days. During this repopulation of the skin by LC, the tumours begin to decrease in size. Since LC function as local cutaneous antigen-presenting cells, and are responsible for initiation of an immune response against antigens in the skin, their depletion during tumour induction may allow DMBA-transformed cells to circumvent the immune system and form tumours. Their reappearance associated with tumour regression suggests that the LC are involved in an immune response against the tumours. | lld:pubmed |
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| pubmed-article:3925975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3925975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3925975 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3925975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3925975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3925975 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3925975 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:3925975 | pubmed:author | pubmed-author:MullerH KHK | lld:pubmed |
| pubmed-article:3925975 | pubmed:author | pubmed-author:HallidayG MGM | lld:pubmed |
| pubmed-article:3925975 | pubmed:author | pubmed-author:KnightB ABA | lld:pubmed |
| pubmed-article:3925975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3925975 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:3925975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3925975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3925975 | pubmed:pagination | 81-5 | lld:pubmed |
| pubmed-article:3925975 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3925975 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3925975 | pubmed:articleTitle | Carcinogen-induced depletion of cutaneous Langerhans cells. | lld:pubmed |
| pubmed-article:3925975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3925975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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