pubmed-article:3923934 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C0553257 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C1879725 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C1158360 | lld:lifeskim |
pubmed-article:3923934 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:3923934 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:3923934 | pubmed:dateCreated | 1985-6-24 | lld:pubmed |
pubmed-article:3923934 | pubmed:abstractText | Stimulation of Madin-Darby canine kidney cells by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) results in an increase in prostaglandin synthesis. We have measured the specific activity of the cyclooxygenase system in a cell-free assay and demonstrate that a fourfold induction occurs by 6 h poststimulation. This induction could be prevented by continuous treatment with either cycloheximide or actinomycin D. When cycloheximide was added to cells 6 h post-TPA stimulation we found only a 50% reduction in prostaglandin synthesis over the ensuing 6 h in vitro; this decrease in activity was not observed when actinomycin was used. On the other hand, cells stimulated with TPA for 6 h and subsequently treated with cycloheximide or actinomycin D ceased prostaglandin synthesis completely within 1 h. These results suggest that TPA stimulation of prostaglandin synthesis requires both transcriptional and translational events but that a factor(s) in addition to or in place of the cyclooxygenase might be crucial. | lld:pubmed |
pubmed-article:3923934 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:language | eng | lld:pubmed |
pubmed-article:3923934 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3923934 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3923934 | pubmed:month | May | lld:pubmed |
pubmed-article:3923934 | pubmed:issn | 0003-9861 | lld:pubmed |
pubmed-article:3923934 | pubmed:author | pubmed-author:WaiteMM | lld:pubmed |
pubmed-article:3923934 | pubmed:author | pubmed-author:DanielL WLW | lld:pubmed |
pubmed-article:3923934 | pubmed:author | pubmed-author:BeaudryG AGA | lld:pubmed |
pubmed-article:3923934 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3923934 | pubmed:day | 15 | lld:pubmed |
pubmed-article:3923934 | pubmed:volume | 239 | lld:pubmed |
pubmed-article:3923934 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3923934 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3923934 | pubmed:pagination | 242-7 | lld:pubmed |
pubmed-article:3923934 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:3923934 | pubmed:meshHeading | pubmed-meshheading:3923934-... | lld:pubmed |
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pubmed-article:3923934 | pubmed:meshHeading | pubmed-meshheading:3923934-... | lld:pubmed |
pubmed-article:3923934 | pubmed:year | 1985 | lld:pubmed |
pubmed-article:3923934 | pubmed:articleTitle | Regulation of arachidonic acid metabolism in Madin-Darby canine kidney cells: stimulation of synthesis of the cyclooxygenase system by 12-O-tetradecanoyl-phorbol-13-acetate. | lld:pubmed |
pubmed-article:3923934 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3923934 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:3923934 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3923934 | lld:pubmed |