| pubmed-article:3915779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:3915779 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:3915779 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:3915779 | pubmed:dateCreated | 1986-10-3 | lld:pubmed |
| pubmed-article:3915779 | pubmed:abstractText | We used haploid yeast cells that express both the MATa and MAT alpha mating-type alleles and contain the spo13-1 mutation to characterize meiotic recombination within single, unpaired chromosomes in Rec+ and Rec- Saccharomyces cerevisiae. In Rec+ haploids, as in diploids, intrachromosomal recombination in the ribosomal DNA was detected in 2 to 6% of meiotic divisions, and most events were unequal reciprocal sister chromatid exchange (SCE). By contrast, intrachromosomal recombination between duplicated copies of the his4 locus occurred in approximately 30% of haploid meiotic divisions, a frequency much higher than that reported in diploids; only about one-half of the events were unequal reciprocal SCE. The spo11-1 mutation, which virtually eliminates meiotic exchange between homologs in diploid meiosis, reduced the frequency of intrachromosomal recombination in both the ribosomal DNA and the his4 duplication during meiosis by 10- to greater than 50-fold. This Rec- mutation affected all forms of recombination within chromosomes: unequal reciprocal SCE, reciprocal intrachromatid exchange, and gene conversion. Intrachromosomal recombination in spo11-1 haploids was restored by transformation with a plasmid containing the wild-type SPO11 gene. Mitotic intrachromosomal recombination frequencies were unaffected by spo11-1. This is the first demonstration of a gene product required for recombination between homologs as well as recombination within chromosomes during meiosis. | lld:pubmed |
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| pubmed-article:3915779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3915779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3915779 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3915779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3915779 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3915779 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3915779 | pubmed:author | pubmed-author:EspositoR ERE | lld:pubmed |
| pubmed-article:3915779 | pubmed:author | pubmed-author:JensenLL | lld:pubmed |
| pubmed-article:3915779 | pubmed:author | pubmed-author:WaddellC SCS | lld:pubmed |
| pubmed-article:3915779 | pubmed:author | pubmed-author:WagstaffJ EJE | lld:pubmed |
| pubmed-article:3915779 | pubmed:author | pubmed-author:KlapholzSS | lld:pubmed |
| pubmed-article:3915779 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3915779 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3915779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3915779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3915779 | pubmed:pagination | 3532-44 | lld:pubmed |
| pubmed-article:3915779 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:3915779 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3915779 | pubmed:articleTitle | Meiotic exchange within and between chromosomes requires a common Rec function in Saccharomyces cerevisiae. | lld:pubmed |
| pubmed-article:3915779 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3915779 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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