| pubmed-article:3814475 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0033572 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C1704448 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0014911 | lld:lifeskim |
| pubmed-article:3814475 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:3814475 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3814475 | pubmed:dateCreated | 1987-4-3 | lld:pubmed |
| pubmed-article:3814475 | pubmed:abstractText | Testosterone-induced DNA synthesis in cultured rat ventral prostate was used to compare the direct effects of Estracyt and Emcyt with that of their metabolite, estramustine, and their carrier-hormone, oestradiol-17 beta on prostatic growth. In serum-supplemented medium (5-20% FCS), all the compounds were equally effective in suppressing testosterone stimulated DNA synthesis which was reduced by between 40-50%, whereas in serum-free medium the estramustine compounds were consistently less effective than oestradiol-17 beta. In the presence of 4 X 10(-9) M testosterone in serum-free medium, stimulated DNA synthesis was reduced by 15-30% following incubation with 4 X 10(-7) M of Estracyt, Emcyt and estramustine and by 60% with 4 X 10(-7) M oestradiol-17 beta. Thus, none of the estramustine compounds appear to offer any selective advantage over that of oestradiol-17 beta in suppressing prostatic DNA synthesis at the target tissue level. | lld:pubmed |
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| pubmed-article:3814475 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3814475 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3814475 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3814475 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3814475 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3814475 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3814475 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:3814475 | pubmed:author | pubmed-author:RichesA CAC | lld:pubmed |
| pubmed-article:3814475 | pubmed:author | pubmed-author:BuchananL JLJ | lld:pubmed |
| pubmed-article:3814475 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3814475 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:3814475 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3814475 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3814475 | pubmed:pagination | 47-51 | lld:pubmed |
| pubmed-article:3814475 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3814475 | pubmed:meshHeading | pubmed-meshheading:3814475-... | lld:pubmed |
| pubmed-article:3814475 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3814475 | pubmed:articleTitle | Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives. | lld:pubmed |
| pubmed-article:3814475 | pubmed:publicationType | Journal Article | lld:pubmed |
