| pubmed-article:3790610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3790610 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:3790610 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:3790610 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:3790610 | lifeskim:mentions | umls-concept:C1882727 | lld:lifeskim |
| pubmed-article:3790610 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:3790610 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3790610 | pubmed:dateCreated | 1987-2-19 | lld:pubmed |
| pubmed-article:3790610 | pubmed:abstractText | The uptake and metabolism of 3H-labeled platelet-activating factor by interstitial and epithelial cells from rat lungs was investigated. The uptake of 1-O-[3H]octadecyl-2-acetyl-sn-glycero-3-phosphocholine (3H-AGEPC) by alveolar type-II cells was linear with time from 5 to 60 min, with an average rate of 660 and 450 fmol/10(6) cells for cells in primary culture for 48 to 72 h, respectively. AGEPC was rapidly metabolized and by 10 min 60% of AGEPC was converted into long-chain acylphosphatidylcholine (PC) (50%) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-GEPC) (10%). By 60 min radioactivity in AGEPC was less than 10% of the total intracellular activity. Lyso-GEPC remained at about 10% throughout the incubation period. The uptake of 3H-AGEPC by fibroblasts was very similar to type II cells, but the rate of metabolism was slower. AGEPC in fibroblasts constituted 85% of the cellular counts after 10 min of incubation, and 50% by 60 min. After 60 min only 30% of the AGEPC was converted to alkylacyl-PC. Characterization of the fatty acids in the alkylacyl-PC of both the type-II cells and lung fibroblasts indicated that arachidonic acid was preferentially (more than 90%) inserted at the 2-position. | lld:pubmed |
| pubmed-article:3790610 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3790610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3790610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3790610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3790610 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3790610 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:3790610 | pubmed:author | pubmed-author:HanahanD JDJ | lld:pubmed |
| pubmed-article:3790610 | pubmed:author | pubmed-author:KumarRR | lld:pubmed |
| pubmed-article:3790610 | pubmed:author | pubmed-author:KingR JRJ | lld:pubmed |
| pubmed-article:3790610 | pubmed:author | pubmed-author:MartinH MHM | lld:pubmed |
| pubmed-article:3790610 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3790610 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:3790610 | pubmed:volume | 917 | lld:pubmed |
| pubmed-article:3790610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3790610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3790610 | pubmed:pagination | 33-41 | lld:pubmed |
| pubmed-article:3790610 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:meshHeading | pubmed-meshheading:3790610-... | lld:pubmed |
| pubmed-article:3790610 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3790610 | pubmed:articleTitle | Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. | lld:pubmed |
| pubmed-article:3790610 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3790610 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3790610 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3790610 | lld:pubmed |
