| pubmed-article:3778217 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0015811 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0031448 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0037494 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0813203 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0232105 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:3778217 | lifeskim:mentions | umls-concept:C0857121 | lld:lifeskim |
| pubmed-article:3778217 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3778217 | pubmed:dateCreated | 1986-12-16 | lld:pubmed |
| pubmed-article:3778217 | pubmed:abstractText | The in vitro responsiveness of rat aortic and femoral arterial smooth muscle from normotensive and deoxycorticosterone acetate (DOCA)/NaCl-induced hypertensive rats to potassium chloride (KCl) and isoproterenol (ISO) in the presence and absence of the alpha-adrenergic blocker phentolamine was investigated. Femoral but not aortic smooth muscle from the DOCA/NaCl rat exhibited an enhanced sensitivity to KCl stimulation when compared to controls. Phentolamine had no effect on femoral smooth muscle from control or DOCA/NaCl rats. However, a significant decrease in the sensitivity of aortic smooth muscle responsiveness to KCl in the presence of phentolamine was observed in both the control and hypertensive groups. Isoproterenol-induced relaxation of both aortic and femoral smooth muscle was significantly attenuated in the DOCA/NaCl rat when compared to controls. Incubation with phentolamine resulted in a significant increase in the relaxation response to ISO in aortic and femoral smooth muscle from controls. This increased responsiveness, however, was not observed in DOCA/NaCl rats. The contractile response to high doses of ISO was attenuated with phentolamine in all groups. A significant increase in the sensitivity to norepinephrine (NE) was observed in both aortic and femoral smooth muscle from the DOCA/NaCl rat when compared to controls. Whereas aortic and femoral smooth muscle from the DOCA/NaCl rat which had been exposed to phentolamine previously in the experiment exhibited a significant decrease in the sensitivity to NE following a one hour washout of the phentolamine, no long-lasting effect of phentolamine was apparent in vessels from controls. The results of this study confirm previous studies that the vascular smooth muscle responsiveness to NE is increased and ISO-induced relaxation is decreased in the DOCA/NaCl rat and demonstrate that these altered adrenergic responses are similarly manifested in the femoral smooth muscle.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
| pubmed-article:3778217 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3778217 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3778217 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3778217 | pubmed:issn | 0098-6127 | lld:pubmed |
| pubmed-article:3778217 | pubmed:author | pubmed-author:FieldF PFP | lld:pubmed |
| pubmed-article:3778217 | pubmed:author | pubmed-author:KatovichM JMJ | lld:pubmed |
| pubmed-article:3778217 | pubmed:author | pubmed-author:SoltisE EEE | lld:pubmed |
| pubmed-article:3778217 | pubmed:author | pubmed-author:SoltisT DTD | lld:pubmed |
| pubmed-article:3778217 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3778217 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:3778217 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3778217 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3778217 | pubmed:pagination | 325-39 | lld:pubmed |
| pubmed-article:3778217 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3778217 | pubmed:meshHeading | pubmed-meshheading:3778217-... | lld:pubmed |
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| pubmed-article:3778217 | pubmed:meshHeading | pubmed-meshheading:3778217-... | lld:pubmed |
| pubmed-article:3778217 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3778217 | pubmed:articleTitle | Differential effects of phentolamine on the responsiveness of aortic and femoral smooth muscle from normotensive and DOCA/NaCl hypertensive rats. | lld:pubmed |
| pubmed-article:3778217 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3778217 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3778217 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
