| pubmed-article:3734138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3734138 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:3734138 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:3734138 | lifeskim:mentions | umls-concept:C1512045 | lld:lifeskim |
| pubmed-article:3734138 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3734138 | pubmed:dateCreated | 1986-9-18 | lld:pubmed |
| pubmed-article:3734138 | pubmed:abstractText | Stable-isotope tracer methods are described for answering the following questions about a drug: Does the drug exhibit dose-dependent changes in pharmacokinetic properties? What are the drug's Michaelis constant (Km) and maximum velocity (Vmax) for enzymatic biotransformation; Are the dose-dependent pharmacokinetic changes great enough to be clinically important? and Which routes of the drug's biotransformation are responsible for the drug's dose-dependent pharmacokinetic properties? Illustrative data are provided from tracer studies performed with a drug with dose-dependent pharmacokinetic properties, phenytoin, and a drug that does not exhibit dose-dependent pharmacokinetic properties, phenobarbital. The advantages and disadvantages of the described stable-isotope methods are discussed. | lld:pubmed |
| pubmed-article:3734138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3734138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3734138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3734138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3734138 | pubmed:issn | 0091-2700 | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:GreenblattD... | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:EvansJ EJE | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:EvansB ABA | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:SchumacherG... | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:BrowneT RTR | lld:pubmed |
| pubmed-article:3734138 | pubmed:author | pubmed-author:SzaboG KGK | lld:pubmed |
| pubmed-article:3734138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3734138 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:3734138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3734138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3734138 | pubmed:pagination | 463-8 | lld:pubmed |
| pubmed-article:3734138 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:meshHeading | pubmed-meshheading:3734138-... | lld:pubmed |
| pubmed-article:3734138 | pubmed:articleTitle | Pharmacokinetics: dose-dependent changes. | lld:pubmed |
| pubmed-article:3734138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3734138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3734138 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
